Purpose of the study . Evaluation antioxidant status and DNA damage in tissues subcutaneous xenografts non-small cell lung cancer peritumoral created using A549 H1299 cultures. Materials methods The included 35 intact male Balb/c Nude immunodeficient mice. Cell lines were used as transplantable tumor biomaterial. A CDX model was accordance with protocol for supratentorial injections (Ozawa T., ...

Two unusual variants of cholinesterase (acylcholineacylhydrolase, 3.1.1.8) have been recognized by the use of differential inhibitors (Kalow and Genest, 1957; Harris and Whittaker, 1961). A third variant, the silent gene, determines an absent or greatly reduced serum cholinesterase level in the affected homozygote (Liddell, Lehmann, and Silk, 1962). These variants are alleles, and the affected ...

The effect of different L-phenylalanine (Phe) concentrations (0.1-12.1 mM), on acetylcholinesterase (AChE) and Na+,K(+)-ATPase activities of brain homogenate and pure enzymes, was investigated at 37 degrees C. AChE and Na+,K(+)-ATPase activities were determined according to Ellman G. L., Courtney D., Andres V. and Featherstone R. M. (1961), Biochem. Pharmacol. 7, 88-95 and Bowler K. and Tirri R...

BACKGROUND Lyme borreliosis is a tick-transmitted, chronic, zoogenous disease caused by Borrelia burgdorferi spirochete. The clinical picture of Lyme disease is characterized by the variety of tissue and organ involvement and differing severity of symptoms. One of the pathogenic symptoms of early Lyme disease is a skin lesion called erythema migrans. MATERIAL AND METHODS The purpose of our re...

In 1943 Henrik Sj6gren first described the syndrome which bears his name. It is generally recognized that the diagnosis can be made when any two of the following three features are present: xerostomia with or without salivary gland enlargement, keratoconjunctivitis sicca, and connective tissue disease, usually rheumatoid arthritis (Bunim, 1961; Bloch and Bunim, 1963). The xerostomia and keratoc...

Glycocholate and taurocholate have been shown (Coleman & Holdsworth, 1976; Billington & Coleman, 1978) to release significant amounts of membrane proteins and phospholipid from erythrocytes before the occurrence of significant cell lysis. Our particular interest was to study in detail the release of acetylcholinesterase from human erythrocytes. Heparinized human blood was centrifuged at 2500g f...

Platelet-derived growth factor (PDGF)-C is a novel member of the PDGF family that binds to PDGF alphaalpha and alphabeta receptors. The growth factor domain of PDGF-C (GFD-PDGF-C) was expressed in high yields in Escherichia coli and was purified and refolded from inclusion bodies obtaining a biologically active growth factor with dimeric structure. The GFD-PDGF-C contains 12 cysteine residues, ...

OBJECTIVE To compare the functional results from high and low-grade isolated partial lesions of the supraspinatus tendon of bursal and articular types, after arthroscopic treatment. METHODS Sixty-four patients with isolated partial lesions of the supraspinatus tendon were evaluated. The mean length of follow-up was 76 months (range: 29-193). The mean age was 59 years (range: 36-82). The domin...