Current in vitro systems mimicking bone tissues fail to fully integrate the three-dimensional (3D) microvasculature and bone tissue microenvironments, decreasing their similarity to in vivo conditions. Here, we propose 3D microvascular networks in a hydroxyapatite (HA)-incorporated extracellular matrix (ECM) for designing and manipulating a vascularized bone tissue model in a microfluidic devic...

A framework is formulated within the theory of mixtures for continuum modeling of biological tissue growth that explicitly addresses cell division, using a homogenized representation of cells and their extracellular matrix (ECM). The model relies on the description of the cell as containing a solution of water and osmolytes, and having a porous solid matrix. The division of a cell into two near...

Nonlinear acoustic damping is a key nonlinearity in miniature loudspeakers when the air velocity at high amplitude. Measurement of nonlinear beneficial for predicting and analyzing performance loudspeakers. However, general measuring methods impedance, such as standing-wave tube method or impedance method, are not applicable this scenario because coupled with other system nonlinearities. In stu...

Soils in terrestrial ecosystems store more carbon (C) than plants and the atmosphere combined, and ecosystems’ C dynamics are strongly dependent of nitrogen (N) availability. Moreover, plant production in boreal ecosystems is often limited by low N availability, and N retention in soils is a major constraint on N recirculation to plants. Soil fungi strongly influence C and N interactions in bor...

Çalışmada Türkiye’de kamu iç ve dış borçlanmasının nedenleri 2002-2019 dönemi için incelenmiştir. Çalışmanın uygulama yöntemleri Gecikmesi Dağıtılmış Otoregresif Model (ARDL) Hata Düzeltme Modeli’dir (ECM). sonuçları gerek kısa gerekse uzun dönemde borç stoku üzerinde en güçlü etkiye sahip olan değişkenin cari denge olduğunu ortaya koymuştur. Bunun yanı sıra, borçlanması ile sabit sermaye yatır...

This paper introduces EECM-MPFQ, a fast implementation of the elliptic-curve method of factoring integers. EECM-MPFQ uses fewer modular multiplications than the well-known GMP-ECM software, takes less time than GMP-ECM, and finds more primes than GMP-ECM. The main improvements above the modular-arithmetic level are as follows: (1) use Edwards curves instead of Montgomery curves; (2) use extende...

Mesenchymal stromal/stem cells (MSCs) represent an area being intensively researched for tissue engineering and regenerative medicine applications. MSCs may provide the opportunity to treat diseases and injuries that currently have limited therapeutic options, as well as enhance present strategies for tissue repair. The cellular environment has a significant role in cellular development and dif...

We describe a multiscale model that incorporates force-dependent mechanical plasticity induced by interfiber cross-link breakage and stiffness-dependent cellular contractility to predict focal adhesion (FA) growth and mechanosensing in fibrous extracellular matrices (ECMs). The model predicts that FA size depends on both the stiffness of ECM and the density of ligands available to form adhesion...

Completion of genome sequences for many organisms allows a reasonably complete definition of the complement of extracellular matrix (ECM) proteins. In mammals this "core matrisome" comprises ∼300 proteins. In addition there are large numbers of ECM-modifying enzymes, ECM-binding growth factors, and other ECM-associated proteins. These different categories of ECM and ECM-associated proteins coop...