PURPOSE Most clinicians recommend followup with annual ultrasound for patients with multicystic dysplastic kidney. The aim of this study was to determine whether followup ultrasound provides any clinical benefit. MATERIALS AND METHODS We retrospectively reviewed the charts of 73 patients who were diagnosed with multicystic dysplastic kidney between October 1991 and August 2005. Data were anal...

Previous studies showed reduced activity of the anterior cingulate cortex (ACC) and supplementary motor area during inhibition in children with attention-deficit/hyperactivity disorder (ADHD). This study aimed to investigate deep brain generators underlying alterations evoked potential components triggered by visual GO/NoGO tasks ADHD compared typically developing (TDC). Standardized weighted l...

Fluorescence spectroscopy offers an effective, noninvasive approach to the detection of precancers in multiple organ sites. Clinical studies have demonstrated that fluorescence spectroscopy can provide highly sensitive, specific and cost-effective diagnosis of cervical precancers. However, the underlying biochemical mechanisms responsible for differences in the fluorescence spectra of normal an...

OBJECTIVE Thymosin beta 4 (Tβ4) is a ubiquitous peptide that plays pivotal roles in the cytoskeletal system and in cell differentiation. Recently, a role for Tβ4 has been proposed in experimental and human carcinogenesis, including gastrointestinal cancer. This study was aimed at evaluating the relationship between Tβ4 immunoreactivity and the initial steps of carcinogenesis. METHODS In total...

The acetabular coverage of the femoral head has been assessed in two-dimensions as the projected covered area or the covered angle on plain radiographs. We present a novel method of the three-dimensional assessment of femoral head coverage obtained by evaluating the covered volume of the femoral head in both normal and dysplastic hips. We also assessed the covered angles on the vertical slices ...

BACKGROUND Lysophosphatidic acid (LPA) is a phospholipid growth factor involved in cell proliferation, differentiation, migration, inflammation, angiogenesis, wound healing, cancer invasion, and survival. This study was directed to evaluate the immunoexpression of LPA-1, cell proliferation, apoptosis, and angiogenesis markers in preneoplastic lesions induced with cadmium chloride in rat prostat...

Introduction and Aim: It has been proposed that µ-calpain is responsible for neuronal survival, while m-calpain – the degeneration. can be assumed "susceptibility" to damage factor neurons in different CNS regions depends on content/activity of calpain isoforms. We analyzed mRNA levels activity µ-and structures rats. Materials Methods: After decapitation intact male Wistar rats prefrontal corte...

There is no effective medical treatment for oral precancer, and surgery to remove these lesions is imprecise because abnormal mucosa extends beyond the visible lesion. Development of vectors for tumor-selective viral replication has been a significant advance, and viral lysis is well suited to destruction of oral precancerous mucosa. To facilitate evaluation of new treatments, we engineered dys...

OBJECTIVE Analyze whether the most frequent cases of non-dysplastic leukoplakias, hyperkeratosis (H), acanthosis (A), and hyperkeratosis with acanthosis (HA) have similar cell proliferation rates and to compare them with epithelial dysplastic (ED) leukoplakias and normal oral epithelium (NOE). STUDY DESIGN The sample comprised 10 cases of normal oral epithelium, 10 cases of hyperkeratosis, 10...