We explore theoretically the controls on dissolution of salt A, in an under-saturated brine of salts A and B. We show that, as the concentration of B increases, the dissolution rate of A decreases, for brine of given temperature. We also show that there is a sharper decrease in dissolution rate with increasing concentration, for concentrations of B above a critical value, where B limits the equ...

This paper investigates household dissolution and changes in asset wealth (socio-economic position) in a rural South African community containing settled refugees. Survival analysis applied to a longitudinal dataset indicated that the covariates increasing the risk of forced household dissolution were a reduction in socio-economic position (asset wealth), adult deaths and the permanent outmigra...

We demonstrate the use of modeling and simulation to investigate bioequivalence (BE) concerns raised about generic warfarin products. To test the hypothesis that the loss of isopropyl alcohol and slow dissolution in acidic pH has significant impact on the pharmacokinetics of warfarin sodium tablets, we conducted physiologically based pharmacokinetic absorption modeling and simulation using form...

[1] We argue that diagnostics of excess dissolved calcium carbonate (TA*) above the saturation horizon cannot be unambiguously interpreted in terms of local in situ dissolution. We examine a three-dimensional numerical model of global ocean circulation and biogeochemistry with explicit representation of the formation and dissolution of calcium carbonate. In particular, dissolution is only allow...

PURPOSE Unlike orthodox medicines, specific guidelines for dissolution testing of complementary/alternate (CAMs) and traditional medicines (TMs) have not been developed nor is dissolution testing a requirement for the quality control of such products. In this report, the dissolution of African Potato (AP) products, an African traditional medicine (ATM) which has been ingested by man for a diver...

Introduction Dissolution is a characterization test commonly used by the pharmaceutical industry to guide formulation design and control product quality. Often, it is a required performance test for solid dosage forms,transdermal patches,and suspensions. It is also the only test that measures the rate of in vitro drug release as a function of time, which can reflect either reproducibility of th...

To study the effect of glycerin fatty acid ester (Poem TR-FB) concentrations on the dissolution rate of acetaminophen (APAP), the dissolution and disintegration behaviors of APAP tablets formulated using various lubricants were examined. The change over time in the available surface area of APAP (S(t)), which is in direct contact with solvent, was also analyzed using these dissolution data. In ...

The purpose of this study was to develop a compaction technique to enhance the solubility, dissolution rate and other physicochemical properties of poorly water-soluble drug indomethacin (IM) with different polymers. The IM was compacted with the different polymers like hydroxy propyl methylcellulose (HPMC), Kollicoat IR, Chitosan, Polyvinyl Pyrrolidone without using any binder and solvent. Pol...

One of the most important practical issues in low-temperature fuel-cell catalyst degradation is platinum dissolution. According to the literature, it initiates at 0.6-0.9 VRHE, whereas previous time- and potential-resolved inductively coupled plasma mass spectrometry (ICP-MS) experiments, however, revealed dissolution onset at only 1.05 VRHE. In this manuscript, the apparent discrepancy is addr...

The dissolution kinetics of synthetic hydroxyapatite (HAP) and carbonate-containing HAP powders have been studied in fluoride-containing acetate buffer solutions partially saturated with respect to HAP (K,, = 10-‘15 to IO-“‘). The experimental results indicate that in the ease of HAP powders the dissolution rates become veqr slow when the K,,, values of the dissolution medium are larger than 10...