The ability of Candida albicans to adhere to subendothelial extracellular matrix (ECM) may be important in the pathogenesis of disseminated candidiasis. ECM proteins, such as fibronectin, laminin, and types I and IV collagen bind C. albicans avidly. These proteins all possess heparin-binding domains. The influence of the glycosaminoglycans (GAGS) including heparin, heparan sulfate and dextran s...

Preface Primary Changes in the Recommendations How to Use the Information in This Report Disease-Specific Recommendations Pneumocystis carinii Pneumonia Toxoplasmic Encephalitis Cryptosporidiosis Microsporidiosis Tuberculosis Disseminated Infection with Mycobacterium avium Complex Bacterial Respiratory Infections Bacterial Enteric Infections Infection with Bartonella (Formerly Rochalimaea) Cand...

By generating a calcineurin mutant of the Candida albicans wild-type strain SC5314 with the help of a new recyclable dominant selection marker, we confirmed that calcineurin mediates tolerance to a variety of stress conditions but is not required for the ability of C. albicans to switch to filamentous growth in response to hypha-inducing environmental signals. While calcineurin was essential fo...

Malaria is one of the most common causes of febrile illness in travelers. Coinfections with bacterial, viral, and fungal pathogens may not be suspected unless a patient fails to respond to malaria treatment. Using novel immunohistochemical and molecular techniques, Plasmodium falciparum, Clostridium perfringens, and Candida spp. coinfections were confirmed in a German traveler to Haiti. Plasmod...

C disseminated candidiasis or Hepatosplenic candidiasis (HSC) is a rare and potentially morbid and mortal complication encountered in febrile neutropenic patients. It is generally associated with recovery from neutropenia, and may occur after the treatment of an episode of acute hematogenous candidiasis. Clinical signs and symptoms include fever unresponsive to antibiotics, abdominal pain and t...

Mucormycosis is a disease caused by the fungi belonging to order mucorales which affects mainly immunocompromised patients. These are found in soil and decomposition of plants animals from sporangiospores released air then inhaled resulting infection based on host resistance. The cases increasing conditions with malnutrition, diabetes, steroid therapy acidosis. After aspergillosis candidiasis, ...