نتایج جستجو برای: disseminated bcg and salmonella infection
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BACKGROUND Leucocyte activating chemokines such as CCL2, CCL3, and CXCL8 together with proinflammatory IFNgamma, TNFalpha and downmodulatory IL10 play a central role in the restriction of M. tuberculosis infections, but is unclear whether these markers are indicative of tuberculosis disease severity. METHODOLOGY We investigated live M. tuberculosis- and M. bovis BCG-induced peripheral blood m...
Severe combined immunodeficiency in Brazil: management, prognosis, and BCG-associated complications.
BACKGROUND Severe combined immunodeficiency (SCID) is one of the most severe forms of primary immunodeficiency. The objectives of this study were to analyze the diagnosis, treatment, and prognosis of SCID in Brazil and to document the impact of BCG vaccine. METHODS We actively searched for cases by contacting all Brazilian referral centers. RESULTS We contacted 23 centers and 70 patients fr...
The bacillus Calmette-Guérin (BCG) vaccine is the only licensed vaccine for human use against tuberculosis (TB). Although controversy exists about its efficacy, the BCG vaccine is able to protect newborns and children against disseminated forms of TB, but fails to protect adults against active forms of TB. In the last few years, interest in the mucosal delivery route for the vaccine has been in...
Nine of 355 cases of symtopmatic HIV-infected children who admitted to Chiang Mai University Hospital from January 1989 to December 1994 had complication due to BCG vaccination. The median age was 15 months with its range from 8 to 22 monts. Four cases presented with ulceration of the previously-healed BCG scar with ipsilateral enlarged and inflamed axillary nodes. Four cases had ipsilateral en...
CD4(+) T cells are central in mediating granuloma formation and limiting growth and dissemination of mycobacterial infections. To determine whether T cells responding to influenza infection can interact with T cells responding to Mycobacterium bovis bacille Calmette-Guérin (BCG) infection and disrupt granuloma formation, we infected mice containing two monoclonal T cell populations specific for...
BACKGROUND There is a need for new vaccines for tuberculosis (TB) that protect against adult pulmonary disease in regions where BCG is not effective. However, BCG could remain integral to TB control programmes because neonatal BCG protects against disseminated forms of childhood TB and many new vaccines rely on BCG to prime immunity or are recombinant strains of BCG. Interferon-gamma (IFN-gamma...
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