نتایج جستجو برای: disposition kinetics
تعداد نتایج: 108195 فیلتر نتایج به سال:
The underpricing of initial public offerings is a well-documented fact of empirical equity market research. Theories explain this underpricing with market imperfections. We study three empirically relevant IPO mechanisms under almost perfect market conditions in the laboratory: a stylized book building approach, a closed book auction, and an open book auction. We report underpricing in each of ...
The kinetics of the disposition of MRK16, an anti-P-glycoprotein monoclonal antibody, was studied in two human colorectal tumor cell lines, HCT-15 and COLO205, whose P-glycoprotein expression is extensive and poor, respectively. In a series of in vitro binding studies, the amount of MRK16 associated with HCT-15 cells at steady state was approximately 40 times greater than that associated with C...
Introduction: Critical thinking is a key element of mental health. The aim of this study was to investigate the relationship critical thinking disposition, self-esteem, assertiveness, Social anxiety and worry within the framework a causal model. Methods: The Present study was a descriptive correlational design of a type path analysis. The study population included a...
Aims and background: This study aimed to evaluate the structural model of the relationship between pain disposition, catastrophizing, fear of pain and pain adjustment in patients with Chronic musculoskeletal pain. Materials and Methods: 314 Patients with chronic musculoskeletal pain wete selected using convenience sampling method among clients of pain clinics in Isfahan, based on pain speciali...
Background & Aim: Critical thinking is a necessary and important component of nursing profession. Since nurses are not limited to work under predetermined roles and need to meet various needs of patients, they should have critical thinking skills. This study aimed to determine the role of emotional intelligence and its components in critical thinking disposition . Methods & Materials: In...
Introduction: Development of students' critical thinking abilities is one of the greatest challenges for nursing educators. Identifying its barriers and resolving them can help to improve critical thinking. The aim of this research was to assess and compare Critical Thinking Disposition (CTD) and its relationship with State Anxiety (SA) in baccalaureate nursing students of Islamic Azad Universi...
BACKGROUND Quantum dots (QDs) are autofluorescent semiconductor nanocrystals that can be used for in vivo biomedical imaging. However, we know little about their in vivo disposition and health consequences. OBJECTIVES We assessed the tissue disposition and pharmacokinetics of QD705 in mice. METHODS We determined quantitatively the blood and tissue kinetics of QD705 in mice after single intr...
S-CKD602 is a PEGylated liposomal formulation of CKD-602, a potent topoisomerase I inhibitor. The objective of this study was to characterize the bidirectional pharmacokinetic-pharmacodynamic (PK-PD) interaction between S-CKD602 and monocytes. Plasma concentrations of encapsulated CKD-602 and monocytes counts from 45 patients with solid tumors were collected following intravenous administration...
PURPOSE Romidepsin is a potent histone deacetylase inhibitor under clinical development. The objective of this study was to evaluate the effect of demographic, clinical, and pharmacogenetic covariates on the pharmacokinetics of romidepsin in patients with T-cell lymphoma. EXPERIMENTAL DESIGN Pharmacokinetic assessment was done in 98 patients enrolled in a phase II study who received 14 or 18 ...
This paper analyzes the relationship between fund flow and fund managers' trading behavior with regard to the disposition effect, which is as the tendency of fund managers cash more winner stocks of portfolio holdings rather than losers. The evidence shows that the disposition effect (DE) exists among professional fund managers and the effect is linearly and negatively correlated with the magni...
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