An in vivo murine model for immunodeficiency of both B and T cells is produced by continuous intraperitoneal infusion of 2'-deoxycoformycin (DCF), a specific tightly binding inhibitor of adenosine deaminase (ADase; adenosine aminohydrolase, EC 3.5.4.4). After DCF infusion, ADase of thymus, spleen, and lymph nodes was inhibited to varying degrees ranging from 57% to 100%. Immunodeficiency under ...

The medium access control (MAC) technique of standard WLANs, called the distributed coordination function (DCF), is carrier sense multiple access based on collision avoidance (CSMA/CA) scheme with binary slotted exponential backoff. It has a two way handshaking technique for packet transmission and also defines an additional four way handshaking technique called RTS/CTS mechanism, which is used...

The finding of elevated intracellular levels of adenosine deaminase (ADA) in some patients with acute lymphoblastic leukemia has led to attempts to control this disease with the adenosine deaminase inhibitor 2'-deoxycoformycin (dCF). Because of clinical reports indicating its relative freedom from myelotoxicity, we have tested the effects of this drug on erythroid, granulocytic, and T-lymphocyt...

In IEEE 802.11 wireless LANs, the DCF access method and the PCF access method operate alternatively within a superframe to service the time-varying traffic demands. Due to different medium access mechanisms deployed by DCF and PCF, they work well for some particular types of traffic scenarios respectively, while their performance may degrade under some other types of traffic demands. None of th...

We have investigated the use of 2'-deoxycoformycin (DCF), a potent inhibitor of adenosine deaminase (ADA), in the treatment of 4 patients with advanced mycosis fungoides (MF). Since DCF has demonstrated an adverse effect in vitro and in vivo on the survival of leukemia T-cell lines, it appeared reasonable to examine its effect in patients with advanced cutaneous T-cell lymphoma. A total of 8 co...

When used for object tracking, the discriminative correlation filter (DCF) is effective, but its performance often burdened by undesirable boundary effects. Meanwhile, when there too much background information in training samples of DCF, it will be easier to learn area deviating from tracking object. Further, illumination variation, partial/full occlusion, and appearance variations, render res...

Sulfate radicals (SO 4 •- ) reactivity against gram-negative ( E. coli and gram-positive faecalis bacteria Contaminants of Emerging Concern (CECs) (Diclofenac-DCF, Sulfamethoxazole-SMX Trimethoprim-TMP) was investigated through laser flash photolysis (LFP) technique. Analysis the lifetime SO in presence cell-wall compounds CECs allowed determining towards these compounds. Results showed that re...

BACKGROUND Recently, neoadjuvant chemotherapy with docetaxel/cisplatin/5-fluorouracil (NAC-DCF) was identified as a novel strong regimen with a high rate of pathological complete response (pCR) in advanced esophageal cancer in Japan. Predicting pCR will contribute to the therapeutic strategy and the prevention of surgical invasion. However, a predictor of pCR after NAC-DCF has not yet been deve...

A mutant of Escherichia coli unable to metabolize succinate has been used to study the nature of succinate transport in whole cells. It is demonstrated that cells accumulate succinate against a concentration gradient. The uptake of succinate is competitively inhibited by fumarate and malate. The Michaelis constants for the dicarboxylic acids are all in the range of 15 to 30 pM. The accumulation...

Human exposure to toxic metals and metalloids in the environment seldom occurs from a single pure compound. Most environmental exposure profiles are heterogeneous with co-exposure occurring coincident with multiple toxic metal species. This co-exposure to metals and metalloids in complex mixtures can result in a synergistic, additive or even depletive toxic response. The complexity of interacti...