Therapeutic doses of ACTH given daily and maintained for more than 2 years in patients with poly-arthritis do not normally suppress hypothalamic-pituitary-adrenal (HPA) responsiveness to the stresses of insulin hypoglycaemia or surgery (Carter and James, 1970a, b). By contrast, corticosteroids in daily doses equivalent to 7 5 mg. or more of predni-solone will impair pituitary-adrenal function i...

EDITOR,—In cystic fibrosis (CF) chronic respiratory infection is countered by an intense inflammatory reaction. Systemic steroids have been shown to improve lung function and reduce morbidity in patients with CF and reduce markers of chronic inflammation ; however, there are significant side eVects associated with their long term use. Low dose cyclosporin A (CyA) has been shown to be eVective i...

I have read the report of Olivieri et al’ in the May 1, 1994 issue of BLOOD. Although the investigators stated that “in standard practice, treatment options are limited to two: steroid therapy or RBC transfusions,” they ignore our very good results obtained with megadose methylprednisolone (MDMP; initial dose 30 to 100 mgkg/d for 3 days followed progressive halving of the dose every 4 to 7 days...

Reply In response to " Megadose Methylprednisolone (MDMP) for Hemangiomatosis " We are grateful to Dr. Özsoylu for his valuable comments on our case report concerning the treatment of hemangiomatosis with propranolol [1]. One of the issues raised by Dr. Özsoylu is regarding with the terminology used to describe hemangiomatous lesions. Although the term infantile hemangiomatosis could be used so...

EDITOR,—In cystic fibrosis (CF) chronic respiratory infection is countered by an intense inflammatory reaction. Systemic steroids have been shown to improve lung function and reduce morbidity in patients with CF and reduce markers of chronic inflammation ; however, there are significant side eVects associated with their long term use. Low dose cyclosporin A (CyA) has been shown to be eVective i...

To a further understanding of the role of steroid hormones in adrenal disorders, we have prepared free cell system of adrenal cells, using adrenal tissues thai had been removed by operation from (i) cases of Cushing's syndrome due to adrenocortical adenoma or adrenocortical hyperplasia, (ii) a case of primary aldosteronism, and (iii) a patient with virilizing adrenal tumor. Twelve important ste...

An 18-year-old woman with Crohn disease was referred by her gastrointestinal surgeon for treatment of possible peristomal pyoderma gangrenosum (PPG). She had undergone a total proctocolectomy with ileoanal anastomosis when she was 10 years old. Her inflammatory bowel disease (IBD) had been quiescent for a few years; however, she had an acute onset of anal fistulas and pouchitis, which led to a ...

EDITOR,—In cystic fibrosis (CF) chronic respiratory infection is countered by an intense inflammatory reaction. Systemic steroids have been shown to improve lung function and reduce morbidity in patients with CF and reduce markers of chronic inflammation ; however, there are significant side eVects associated with their long term use. Low dose cyclosporin A (CyA) has been shown to be eVective i...

Correspondence To the Editor: In August 2013, a 22-year-old female was referred to a psychiatric hospital with 6 months history of insomnia, suicidal thought, social withdrawal, irritability and persecutory delusion. She was given the diagnosis of schizophrenia and started on risperidone and chlorpromazine, which were stopped abruptly after 1-week due to lack of any improvement in her mental st...

We report a young girl with myasthenia gravis (MG) who was first seen at age 2 for unexplained falls, diplopia, and ptosis. The patient was born as a full-term spontaneous vaginal delivery and spoke her first words and started walking at the age 10 months. The child was physically active initially and loved to play and run. At age 27 months, the patient started having difficulty rising up while...