نتایج جستجو برای: cortical spreading depression

تعداد نتایج: 270778  

Journal: :Brain : a journal of neurology 2005
Olaf Windmüller Ute Lindauer Marco Foddis Karl M Einhäupl Ulrich Dirnagl Uwe Heinemann Jens P Dreier

In rats, cortical spreading hyperaemia is coupled to a spreading neuroglial depolarization wave (spreading depression) under physiological conditions, whereas cortical spreading ischaemia is coupled to it if red blood cell products are present in the subarachnoid space. Spreading ischaemia has been proposed as the pathophysiological correlate of the widespread cortical infarcts abundantly found...

Journal: :The American journal of physiology 1964
C D HULL A VANHARREVELD

HULL, C. D., AND A. VAN HARREVELD. Absence oj conduction of spreading de)wession through cortical region damaged by asphyxiation. Am. J. Physiol. 207(4) : 92 I-924. Ig6+-An area of cerebral cortex was asphyxiated for 30-35 min by application of a weight exerting a pressure on the tissue greater than the blood pressure. Three days later the asphyxiated region showed in most. experiments a marked...

2017
Ryo Tamaki Samuel Ige Orie Beat Alessandri Oliver Kempski Axel Heimann

Endogenous neurogenesis can arise from a variety of physiological stimuli including exercise, learning, or "enriched environment" as well as pathological conditions such as ischemia, epilepsy or cortical spreading depression. Whether all these conditions use a common trigger to set off endogenous neurogenesis is yet unclear. We hypothesized that cortical spreading depression (CSD) induces neuro...

2016
Kenneth K Kwong Suk-tak Chan Giovanni Messina Emanuela Viggiano Vincenzo Monda Antonietta Messina Fiorenzo Moscatelli Anna Valenzano Domenico Tafuri Vincenzo De Luca Giuseppe Cibelli Marcellino Monda

and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, pleas...

Journal: :The International journal of neuroscience 1981
H C Tuckwell C L Hermansen

A reaction--diffusion system of equations whose components are the extracellular concentrations of K+, Ca++, Na+, Cl-, an excitatory neurotransmitter and an inhibitory neurotransmitter, is developed in order to model the movements of these substances through various kinds of membrane in brain structures. Expressions are derived from probabilistic arguments for the conductances induced in subsyn...

Journal: :Journal of immunology 2003
Richard E Jones Dennis Bourdette Nicole Moes Arthur Vandenbark Alex Zamora Halina Offner

The sequential emergence of specific T lymphocyte-mediated immune reactivity directed against multiple distinct myelin epitopes (epitope spreading) has been associated with clinical relapses in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Based on this association, an appealing and plausible model for immune-mediated progression of the advancing c...

Journal: :The Journal of clinical investigation 2004
Yasemin Gursoy-Ozdemir Jianhua Qiu Norihiro Matsuoka Hayrunnisa Bolay Daniela Bermpohl Hongwei Jin Xiaoying Wang Gary A Rosenberg Eng H Lo Michael A Moskowitz

Cortical spreading depression (CSD) is a propagating wave of neuronal and glial depolarization and has been implicated in disorders of neurovascular regulation such as stroke, head trauma, and migraine. In this study, we found that CSD alters blood-brain barrier (BBB) permeability by activating brain MMPs. Beginning at 3-6 hours, MMP-9 levels increased within cortex ipsilateral to the CSD, reac...

2012
J Sonn A Mayevsky

OBJECTIVES OBJECTIVES The effect of cortical spreading depression (CSD) on extracellular K(+) concentrations ([K(+)](e)), cerebral blood flow (CBF), mitochondrial NADH redox state and direct current (DC) potential was studied during normoxia and three pathological conditions: hypoxia, after NOS inhibition by L-NAME and partial ischemia. METHODS A SPECIAL DEVICE (MPA) WAS USED FOR MONITORIN...

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