AIM In experimental studies, nonexcitatory electrical stimulation delivered at the time of absolute myocardial refractoriness resulted in cardiac contractility modulation (CCM) with improved systolic function. This study reports the initial experience with CCM in patients with chronic heart failure. METHODS AND RESULTS Twenty-five patients, 23 males, with a mean age of 62+/-9 years and drug-r...

INTRODUCTION The laser Doppler imaging (LDI) FLARE and corneal confocal microscopy (CCM) are reliable markers of small fibre function (SFF) and structure (SFS), respectively, but the impact of potential confounding variables needs to be defined. The objective of this study was to determine the influence of age, anthropometric and biochemical variables on LDI and CCM. METHODS 80 healthy volunt...

in this paper, the variational homotopy perturbation method (vhpm) and its convergence is adopted for thezakharove-kuznetsov equations (zk-equations). the aim of this paper is to present an efficient and reliabletreatment of the vhpm for the nonlinear partial differential equations and show that this method is convergent.the convergence of the applied method is approved using the method of majo...

although homotopy-based methods, namely homotopy analysis method andhomotopy perturbation method, have largely been used to solve functionalequations, there are still serious questions on the convergence issue of thesemethods. some authors have tried to prove convergence of these methods, butthe researchers in this article indicate that some of those discussions are faulty.here, after criticizi...

With the recent adoption of the CORBA component model (CCM), application programmers now have a standard way to implement, manage, configure, and deploy components that implement and integrate CORBA services. The CCM standard not only enables greater software reuse for servers, it also provides greater flexibility for dynamic configuration of CORBA applications. Thus, CCM appears to be well-sui...

Cardiac contractility modulation (CCM) is a relatively new electrical therapy for heart failure patients with reduced ejection fraction. The majority of patients eligible for CCM will also need an implantable cardioverter-defibrillator (ICD). To-date, three pacing electrodes are mandatory for CCM therapy because the current CCM signal delivery algorithm requires sequential intracardiac sensing ...

Inotropic effects of electric currents applied during the refractory period have been reported in cardiac muscle in vitro using voltage-clamp techniques. We investigated how electric currents modulate cardiac contractility in normal canine hearts in vivo. Six dogs were instrumented to measure regional segment length, ventricular volume (sonomicrometry), and ventricular pressure. Cardiac contrac...

introductioin Cerebral cavernous malformation (CCM), also known as cavernous angioma, is a type of vascular malformation in the central nervous system. To date, rare cases of CCM and seizure have been reported in pregnancies. Nowadays, the management of such condition in pregnancy is still a challenge due to lacking of experiences. We presented a case of pregnant woman with CCM combined with ep...

Glioblastomas (GBMs) are the most common and aggressive malignant primary brain tumors found in humans. In high-grade gliomas, vasculogenic mimicry (VM) is often detected. VM is the formation of de novo vascular networks by highly invasive tumor cells, instead of endothelial cells. An understanding of the mechanisms of VM formation will contribute to the targeted therapy of GBMs. In the present...

Modification of Newtons method with higher-order convergence is presented. The modification of Newtons method is based on Frontinis three-order method. The new method requires two-step per iteration. Analysis of convergence demonstrates that the order of convergence is 6. Some numerical examples illustrate that the algorithm is more efficient and performs better than classical Newtons method and ...