Neonatal lupus erythematosus is a rare, passively acquired autoimmune disease, caused by maternal autoantibodies. The most common manifestations are skin rash and congenital heart block. Cutaneous manifestations may be present at birth, but often develop within a few weeks after delivery. Congenital heart block may present as bradycardia in utero or during physical examination at birth. Approxi...

Neonatal lupus syndrome is a passively acquired autoimmune syndrome in which pathogenic autoantibodies (anti-SSA/Ro, anti-SSB/La, and both, or rarely anti-U(1)RNP antibodies) are transmitted from a mother to her fetus through the placenta. The major clinical manifestations in the infants are cardiac (congenital heart block), dermatologic (skin lesion), hepatic (elevated hepatic enzymes), and he...

background: extracardiac malformations can be seen in 20-45% of infants with congenital heart disease (chd). chromosomal abnormalities exist in 5-10% of patients with chd. the aim of this study was to assess the frequency of overt extra cardiac malformations in children with chd. methods: this descriptive epidemiologic study was conducted on 720 patients with chd referred to the pediatric cardi...

introduction: infective endocarditis (ie) causes serious complications in patients. congenital heart disease (chd) is an important underlying condition in children. case presentation: a 6-year-old girl with ventricular septal defect (vsd) was presented. echocardiography revealed large vegetation in right ventricular outflow tract near the pulmonary valve. the patient showed clinical symptoms of...

conclusions we explain embryologic origin, differential diagnosis, other associated anomalies and its treatment by reviewing literature. introduction midline cleft of mandible, classified as tessier 30 clefts is extremely rare, with less than 100 reported cases in the latest studies. variations in severity and associated malformations have been reported before. case presentation in this report,...

due to advanced treatments in the field of heart disease, cyanotic heart disease patients have a greater chance of survival, and nowadays many of them live until adolescence or middle age. one of the signs of this disease is blood hypoxia, which has acute and chronic effects on the cns. in this paper the effect of chronic hypoxia on children affected by cyanotic congenital heart disease (chd) i...

background : due to the increased prevalence of celiac disease in chromosomal anomalies and other congenital anomalies, this study was conducted to evaluate the seroprevalence of celiac disease (cd) in patients with congenital heart defects (chd). methods: this case-control study was done on 1002 children in two groups of chd patients (n=402) and controls (n=600). the serum tissue transglutamia...

BACKGROUND Congenital complete atrioventricular block without any structural heart disease and anti-Ro/La negativity is very rare. Discordant complete atrioventricular block, which is more frequently defined in the literature as an autoimmune mechanism, is much more rare in monozygotic twins. CASE REPORT The 26-year-old healthy mother had given birth in her first spontaneous, uneventful pregn...