OBJECTIVE To evaluate the protective efficacy of co-trimoxazole prophylaxis against malaria in HIV exposed children (uninfected children born to HIV infected mothers) in Africa. DESIGN Non-blinded randomised control trial SETTING Tororo district, rural Uganda, an area of high malaria transmission intensity PARTICIPANTS 203 breastfeeding HIV exposed infants enrolled between 6 weeks and 9 m...

The Molecular Epidemiology of Malaria in Western Kenya Malaria epidemiology reflects a complex web of inter-related factors: host, parasite, vector and environment. The nature, duration and severity of malaria infection depend upon these fixed and changing factors, and are complicated by varying levels of acquired immunity in individuals. The present research used molecular biology tools to exa...

BACKGROUND & OBJECTIVES The increase in Plasmodium falciparum infections which are associated with severe and complicated malaria and drug resistance has made control of malaria a difficult task. Extensive genetic polymorphism in P. falciparum has been reported from several parts of the world which affects the efficacy of sub-unit vaccines. The knowledge of genotypes of the parasite in a geogra...

BACKGROUND Malaria is a common and important infection in travelers. METHODS We have examined data reported to the GeoSentinel surveillance network to highlight characteristics of malaria in travelers. RESULTS A total of 1140 malaria cases were reported (60% of cases were due to Plasmodium falciparum, 24% were due to Plasmodium vivax). Male subjects constituted 69% of the study population. ...

T mere mention of malaria evokes visions of the devastating effects of this still unconquered disease. Just how much damage it inflicts is highlighted by a recent observational study of the natural history of complicated falciparum malaria reported in this issue1 of the journal. The authors found cerebral malaria, jaundice and renal failure as the most common combination of multiorgan dysfuncti...

INTRODUCTION Malaria is a preventable and curable disease. Mazowe district had been experiencing a lower malaria transmission rate in comparison to other districts in the Mashonaland Central province but it experienced a huge outbreak in the 2013-2014 rainy seasons with a case fatality rate (CFR) of 0.21%. This CFR was the highest in the province and it was twice as much as the national CFR (0....

Considering malaria is a highly devastating disease of mankind, total eradication of malaria seems to be an uphill task, the only relief from this disease is achieved by usage of antimalarial drugs. Since malaria is associated with humans from time immemorial, usage of traditional substances to most presently effective antimalarial have been recorded to cure this disease. With the advent of mod...

Malaria is currently one of the most serious public health problems in Colombia with an endemic/epidemic transmission pattern that has maintained endemic levels and an average of 105,000 annual clinical cases being reported over the last five years. Plasmodium vivax accounts for approximately 70% of reported cases with the remainder attributed almost exclusively to Plasmodium falciparum. A limi...