Colorectal cancer is the third most common in men and second women globally. There a marked variation incidence of colorectal carcinoma worldwide, where western countries having high rate compared to others. p53 tumour suppressor gene one intensively studied markers tumours. Two were used, (oncoprotein p53) CEA (carcinoembryonic antigen) study. The 102 cases paraffin-embedded samples processed ...

BACKGROUND Numerous cancers have been linked to microorganisms. Given that colorectal cancer is a leading cause of cancer deaths and the colon is continuously exposed to a high diversity of microbes, the relationship between gut mucosal microbiome and colorectal cancer needs to be explored. Metagenomic studies have shown an association between Fusobacterium species and colorectal carcinoma. Her...

Dysregulation of the cylindromatosis (CYLD) gene has been involved in various cancer entities, including colorectal carcinoma (CRC). However, the expression profile and clinical significance of CYLD in patients with a series of colorectal lesions are yet to be clear. In this study, we analyzed the difference of CYLD gene expression among 19 normal colorectal mucosae, 60 colorectal adenoma tissu...

Many but not all of the cell surface antigens studied were released into tissue culture medium of human colorectal carcinoma and melanoma cells maintained in vitro. Two groups of monoclonal antibody-defined antigens are described. One group is composed of molecules that are released easily and in large quantitites into the tissue culture milieu. In this group, four glycolipid antigens of colon ...

Secretion of several cytokines by colorectal carcinoma cells has been substantiated. These do not include granulocyte-macrophage colony-stimulating factor (GM-CSF) thus far. We show that the supernatant of two human colorectal carcinoma cell lines, LS1034 and SW480, stimulates proliferation of GM-CSF-dependent M07e cells. The activity was constitutively secreted by LS1034 cells and could be ind...

Introduction Lynch syndrome (LS), the most common hereditary colorectal cancer syndrome, is characterized by mutations in mismatch repair (MMR) genes leading to an increased cancer risk, namely colorectal cancer. Case In the context of surveillance colonoscopy, a 40-mm flat lesion (0-IIa+b, Paris classification) was identified and submitted to piecemeal mucosal endoscopic resection in a 64-ye...

Classical segregation analysis was conducted on 605 families of probands with colorectal carcinoma ascertained through the Cancer Registry of the Province of Modena in Italy. The families were classified as 28 suspected hereditary non-polyposis colorectal cancer (HNPCC) syndromes and 577 presumed non-HNPCC. In 11 of these, both parents had colorectal carcinoma, in 130 one parent was affected, a...

Metastasis is one of the primary obstacles to the successful treatment of colorectal cancer. Teng-Long-Bu-Zhong-Tang (TLBZT) is a modern Chinese herbal formula that may be useful in the treatment of metastatic colorectal cancer. The present study evaluated the effects of TLBZT on lung metastasis in human RKO colon carcinoma cells injected into mice via the tail vein. The results demonstrated th...

Endoscopic resection of colorectal polyps is a well-recognised therapy for the prevention of colorectal carcinoma. Roughly 10% of resected polyps contain foci of carcinoma and are of‐ ten termed malignant polyps or polyp cancers. Their incidence is increasing in line with the increasing use of colonoscopy.[1] A proportion of these will have progressed to nodal dis‐ ease before presentation and ...

BACKGROUND Currently, there is no standard salvage regimen after the failure of cisplatin-based chemotherapy for advanced urothelial carcinoma. The combination of epidermal growth factor receptor inhibitor with fluorouracil, leucovorin, and irinotecan was originally designed for the treatment of metastatic colorectal cancer. Until now, there have been no reports using this combination therapy i...