ABSTRACT Introduction Terumo BCT is developing a system to produce freeze-dried plasma product, Terumo’s (TFDP), that stored in rugged, light-weight plastic package suitable for field use, which retains stable level of specific coagulation factors and proteins within clinical range, when up 2 years at room temperature 4°C. Materials Methods Plasma frozen 24 hours phlebotomy (PF24) were thawed, ...

Amniotic fluid embolism (AFE) is an uncommon obstetric condition involving pregnant women during labor or in the initial stages after delivery. Its incidence is estimated to be around 5.5 cases per 100,000 deliveries. Therefore, this paper investigated the pathophysiological mechanism, which underlies AFE, in order to evaluate the role of immune response in the development of this still enigmat...

Background. Excessive intraoperative bleeding during scoliosis correction extends surgery time, and may increase the risk of complications during surgery and the postoperative period. Recombinant factor VIIa (rVIIa) is widely used to control hemorrhage in patients with hemophilia. Recent reports have examined the use of rVIIa for intraoperative bleeding in patients without coagulopathies. The a...

Trousseau first reported over 100 years ago that cancer patients have an increased incidence of coagulopathies (1). Since Trousseau published his findings, thromboembolic disorders have been documented at elevated frequencies in patients with a wide variety of tumors such as lung, pancreas, stomach, and colon tumors (2). These clinical findings have been supported by laboratory studies that hav...

Hematological abnormalities associated with the diabetic state include reduced platelet function, enhanced factor activation and hyperfibrinolysis. The present investigation evaluated blood loss and the transfusion requirements in diabetic and non-diabetic patients undergoing extracorporeal circulation and cardiac surgery. A retrospective study of 151 consecutive patients undergoing primary cor...

BACKGROUND The hemostatic system of children changes with age and differs significantly from the hemostatic system of adults. Age-specific reference values are therefore required for most hemostatic variables. Thromboelastography (TEG) is a point-of-care coagulation test that may provide superior evaluation and management of coagulopathies after cardiac surgery, when large-dose unfractionated h...

BACKGROUND Current coagulation tests lack sensitivity and detect disseminated intravascular coagulation (DIC) only when it is severe. Measurement of antithrombin (AT) activity and D-dimer concentration permits early diagnosis and more precise classification of coagulopathies in some species. OBJECTIVES The objectives of this study were to validate and determine the diagnostic utility of a chr...

We utilized a kaolin-activated partial thromboplastin time (APTT) using rabbit brain phospholipid, in which the capacity of a fourfold increased "high" phospholipid concentration (PC) to normalize the abnormal "standard" PC-APTT in patients with lupus anticoagulants is assessed. This system was also used to measure factors VIIIC, IX, and XI. The tissue thromboplastin inhibition test (TTI), a pr...

Introduction. Liver disease patients have complex hemostatic defects leading to a delicate, unstable balance between bleeding and thrombosis. Conventional tests such as PT and APTT are unable to depict these defects completely. Aims. This study aimed at analyzing the abnormal effects of liver disease on sonoclot signature by using sonoclot analyzer (which depicts the entire hemostatic pathway) ...

Postpartum haemorrhage (PPH) is a major risk factor for maternal morbidity and mortality. PPH has numerous causative factors, which makes its occurrence and severity difficult to predict. Underlying haemostatic imbalances such as consumptive and dilutional coagulopathies may develop during PPH, and can exacerbate bleeding and lead to progression to severe PPH. Monitoring coagulation status in p...