Migraine is a primary headache disorder which has received little attention from health care policies and physicians. This has led to ineffective management and more suffering to the patients and society. Migraine per se is a disabling disease which has its impact on the patient, family and work. It is associated with high incidence of psychiatric co-morbidities, especially depression and anxie...

Sodium valproate is a broad-spectrum anticonvulsant drug that has been on the UK market since 1973​[1]​. In UK, it licensed for treatment of epilepsy and bipolar disorder can also be considered in patients with episodic or chronic migraine​[2]​. Commonly used brands include Dyzantil (Aspire Pharma), Epilim (Sanofi), Episenta […]

Andreou AP, Sprenger T, Goadsby PJ. Cortical spreading depression-evoked discharges on trigeminothalamic neurons. Headache. 2012;52:900. Monteith TS, Goadsby PJ, Shapiro RE. Eliminating the burden of chronic migraine and posttraumatic headache in military and civilian populations. Headache. 2012;52:869. Hoffmann J, Park JW, Storer RJ, Goadsby PJ. Magnesium and memantine do not inhibit nocicepti...

This study, which is a part of the initiative 'Lifting The Burden: The Global Campaign to Reduce the Burden of Headache Worldwide', assesses and presents all existing evidence of the world prevalence and burden of headache disorders. Population-based studies applying International Headache Society criteria for migraine and tension-type headache, and also studies on headache in general and 'chro...

OBJECTIVE To describe headache-related health resource usage in chronic and episodic migraine across six countries. METHODS A web-based questionnaire eliciting data on several topics, including health resource usage, was administered to panellists with migraine from the USA, Canada, UK, Germany, France and Australia. Respondents were grouped into episodic and chronic migraine, based on report...

OBJECTIVE To better define, in women with headache, the relationship of depression and somatic symptoms to headache, characterized by diagnoses, frequency, and disability. METHODS At six headache specialty clinics, women with headache were classified using ICHD-II criteria, and frequency was recorded. A questionnaire addressing demographics, age at onset of headache, headache-related disabili...

Migraine is a chronic disease characterized by unilateral, pulsating, and often moderate-to-severe recurrent episodes of headache with nausea and vomiting. It affects approximately 15% of the general population, yet the underlying pathophysiological mechanisms are not fully understood. Optical coherence tomography (OCT) is a safe and reproducible diagnostic technique that utilizes infrared wave...

Introduction Migraine is a chronic disease that affects about 15% of world's population. It the most disabling among men and women under 50 years. Studies indicate caffeine, which consumed stimulating in world present on daily diet, can be related to migraine an ambiguous way. ObjectiveConsidering epidemiologic economic point view, phisiopatology accessibility this study aims understand if ther...