نتایج جستجو برای: chop

تعداد نتایج: 4508  

Journal: :Journal of Cell Biology 2002

2012
So Yeon Kim Dong-Yeop Shin Seung-Sook Lee Cheolwon Suh Jae-Yong Kwak Hoon-Gu Kim Jae Hoon Lee Soon Il Lee Ye Rim Lee Seung Hwa Kang Se Kwon Mun Min Jae Lee Hyo-Rak Lee Sung Hyun Yang Hye Jin Kang

BACKGROUND This study evaluates the effectiveness of immunochemotherapy and radiation therapy in the treatment of patients with primary bone lymphoma (PBL). METHODS We retrospectively reviewed the medical records of 33 patients with PBL who were treated at 6 medical centers in Korea from 1992 to 2010. Clinicopathological features and treatment outcomes were analyzed. RESULTS The median age ...

2007
Yoan Chérasse Anne-Catherine Maurin Cédric Chaveroux Céline Jousse Valérie Carraro Laurent Parry Christiane Deval Christophe Chambon Pierre Fafournoux Alain Bruhat

When an essential amino acid is limited, a signaling cascade is triggered that leads to increased translation of the 'master regulator', activating transcription factor 4 (ATF4), and resulting in the induction of specific target genes. Binding of ATF4 to the amino acid response element (AARE) is an essential step in the transcriptional activation of CHOP (a CCAAT/enhancer-binding protein-relate...

Journal: :International journal of clinical and experimental medicine 2015
Shao-Jie Bi Chun-Yan Wang Juan Zhang Zhao-Peng Lv Yi-Xin Li

BACKGROUND Macrophage apoptosis triggered by endoplasmic reticulum (ER) stress contributes much to atherosclerosis, especially plaque vulnerability. Activating transcription factor 4 (ATF4)-CCAAT/enhancer binding protein (C/EBP) homologous protein (CHOP)-Tribbles 3 (TRIB3) pathway is closely related to the ER stress. This study aimed to investigate the effect of atorvastatin on the ATF4-CHOP-TR...

2014
Yong Zhou Furong Shu Xinyu Liang Hui Chang Linying Shi Xiaoli Peng Jundong Zhu Mantian Mi

Ampelopsin (AMP), a major bioactive constituent of Ampelopsis grossedentata, exerts a number of biological effects. In this study, we investigated its anti-cancer activity in human breast cancer cell lines, and explored the underlying mechanism of this action. Our results showed that treatment with AMP dose-dependently inhibited cell viability and induced apoptosis in MCF-7 and MDA-MB-231 breas...

Journal: :Molecular cancer therapeutics 2009
Claudia Forni Mario Minuzzo Emanuela Virdis Elena Tamborini Matteo Simone Michele Tavecchio Eugenio Erba Federica Grosso Alessandro Gronchi Pierre Aman Paolo Casali Maurizio D'Incalci Silvana Pilotti Roberto Mantovani

Differentiation is a complex set of events that can be blocked by rearrangements of regulatory genes producing fusion proteins with altered properties. In the case of myxoid liposarcoma (MLS) tumors, the causative abnormality is a fusion between the CHOP transcription factor and the FUS or EWS genes. CHOP belongs to and is a negative regulator of the large CAAT/enhancer binding protein family w...

2007
Laurie H. Sehn Brian Berry Mukesh Chhanabhai Catherine Fitzgerald Karamjit Gill Paul Hoskins Richard Klasa Kerry J. Savage Tamara Shenkier Judy Sutherland Randy D. Gascoyne Joseph M. Connors

Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous entity, with patients exhibiting a wide range of outcomes. The addition of rituximab to CHOP chemotherapy (R-CHOP)has led to a marked improvement in survival and has called into question the significance of previously recognized prognostic markers. Since randomized controlled trials of R-CHOP in DLBCL have included select subgroups of pat...

Journal: :Annals of oncology : official journal of the European Society for Medical Oncology 2010
R Seki K Ohshima T Fujisaki N Uike F Kawano H Gondo S Makino T Eto Y Moriuchi F Taguchi T Kamimura H Tsuda K Shimoda T Okamura

BACKGROUND The F-box protein S-phase kinase-associated protein 2 (Skp2) positively regulates the G1-S transition by promoting degradation of the cyclin-dependent kinase inhibitor p27(kip1) (p27). Recent evidence has indicated an oncogenic role of Skp2 in not only carcinogenesis but also lymphomagenesis. MATERIALS AND METHODS Clinicopathologic features and immunohistochemical expression of Skp...

2014
Yong Won Choi Seong Hyun Jeong Mi Sun Ahn Hyun Woo Lee Seok Yun Kang Jin-Hyuk Choi U Ram Jin Joon Seong Park

Febrile neutropenia (FN) is the major toxicity of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) regimen in the treatment of diffuse large B-cell lymphoma (DLBCL). The prediction of neutropenia and FN is mandatory to continue the planned R-CHOP therapy resulting in successful anti-cancer treatment. The clinical features and patterns of neutropenia and FN from...

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