Acute interstitial nephritis in a patient taking tienilic acid A patient taking the uricosuric diuretic tienilic acid or ticrynafen (2,3-dichloro-4-(2-thienyl-carbonyl) phenoxyacetic acid)-marketed as Selacryn, (Smith, Kline and French Laboratories 62698) developed acute renal failure due to acute allergic interstitial nephritis. Case report A 61-year-old housewife of Lithuanian extraction had ...

1 reported that the combined administration of 2a-methyl-9a-chlorocortisol and sodium phosphate could induce focal necrotic lesions of the myocar-dium. This report was followed by a large number of papers from the same laboratory in which it was reported that many, but not all, adrenal cortical steroids could act in the same way as 2a-methyl-9a-chlorocortisol and that the sodium salts of certai...

symptoms, becoming completely normal after 4 weeks. Fluoxetine was reintroduced at the same dose and the depressive syndrome disappeared without recurrence of toxic effects. A second case, a 57 year old woman, developed a generalised secondary partial epilepsy 3 months after an embolic cerebral infarct. Phenytoin was introduced at 400 mg/ day. A year later the patient developed a depressive syn...

The discovery of the countercurrent multiplier system as the mechanism responsible for the concentration and dilution of the urine has provided a framework for the identification of the site of action of diuretic drugs. Agents that act at a single anatomic site in the nephron can be expected to alter the pattern of urine flow in a predictable way. A drug that acts solely in the proximal convolu...

tive in preventing SMC hypertrophy and hyperploidy than hyperplasia suggest that the signals for SMC hypertrophy are different from those for hyperplasia. However, the specific factors that stimulate aortic SMC hypertrophy and hyperploidy in the SHR are unclear. Three lines of indirect evidence indicate that SMC hypertrophy represents a response to increased blood pressure or wall stress: 1) Ou...

Modern diuretic therapy evolved from 2 seemingly unrelated events in the 1930s: the development of sulfanilamide, the first truly effective antibacterial agent, and the description of the enzyme carbonic anhydrase. Sulfanilamide was observed to increase sodium (Na )/potassium and water excretion by inhibition of carbonic anhydrase activity. Recognition of this action proved the impetus for synt...

Chlorothiazide, the first of the diuretic and antihypertensive benzothiadiazines, was introduced into medical practice in 1958. In 1959 it was followed by hydrochlorothiazide, and since then other similar derivatives, some more potent, some longer acting, have been introduced into therapy. While these compounds were originally used for the treatment of edema and congestive heart failure, physic...

Beta-blockers were one of the first modern medications used for the treatment of blood pressure. Before 1950, treatment options for hypertension were limited. The alphabet soup of medications -reserpine, pentaquine, hydralazine, and guanethidine -were notorious for inducing orthostasis, sedation, constipation, impotence, or blurry vision. Then in the 1960s, propranolol and chlorothiazide were d...

Modern diuretic therapy evolved from 2 seemingly unrelated events in the 1930s: the development of sulfanilamide, the first truly effective antibacterial agent, and the description of the enzyme carbonic anhydrase. Sulfanilamide was observed to increase sodium (Na )/potassium and water excretion by inhibition of carbonic anhydrase activity. Recognition of this action proved the impetus for synt...