Organ‐on‐chip models, developed using microengineering and microfluidic technologies, aim to recreate physiological‐like microenvironments of organs or tissues as a tool study (patho)physiological processes in vitro. On‐chip models bone are relevant for the physiology, diseases regenerative processes. While few bone‐on‐a‐chip exist, recapitulating cellular components bone, these do not incorpor...

Abstract The contact length is one of the most important factors to evaluate chip formation process and mechanical loads in metal cutting. Over years, several methods identify were developed. However, especially for wet cutting processes determination still challenging. In this paper, three dry Ti6Al4V AISI4140 + QT are presented, discussed analyzed. first approach uses tools with a microtextur...

Glioblastoma multiforme (GBM) is the most common and malignant of all human primary brain cancers, in which drug treatment is still one of the most effective treatments. However, existing drug discovery and development methods rely on the use of conventional two-dimensional (2D) cell cultures, which have been proven to be poor representatives of native physiology. Here, we developed a novel thr...

The carboxyl terminus of constitutive heat shock cognate 70 (HSC70)-interacting protein (CHIP, also known as Stub1) is a U box-containing E3 ubiquitin ligase that is important for protein quality control. The role of CHIP in innate immunity is not known. Here, we report that CHIP knockdown inhibits Toll-like receptor (TLR) 4- and TLR9-driven signaling, but not TLR3-driven signaling; proinflamma...

A comprehensive understanding of coral reproduction and development is needed because corals are threatened in many ways by human activity. Major threats include the loss of their photosynthetic symbionts (Symbiodinium) caused by rising temperatures (bleaching), reduced ability to calcify caused by ocean acidification, increased storm severity associated with global climate change and an increa...

Position-dependent cell fate determination and pattern formation are unique aspects of the development of plant structures. The establishment of single-celled leaf hairs (trichomes) from pluripotent epidermal (protodermal) cells in Arabidopsis provides a powerful system to determine the gene regulatory networks involved in cell fate determination. To obtain a holistic view of the regulatory eve...

the aim of this study was to characterize albumin fractions of four different wheat varieties grown in a local climatic context, as well as to find the relationship between the particular albumin fractions and enzyme activity of the tested wheat flours and dough rheological properties. the determined content of albumin fractions ranged from 2.64 to 17.50% of total proteins. more than 50% of the...

Ti-6Al-4 V finds wide applications in industrial areas due to its unique properties. Though, how special microstructure (i.e., properties mismatch between different phases) could influence the surface/chip formation mechanism when machining (e.g., size effect) remains unclear. In this study, cutting experiments, simulation and post-processing materials characterizations of bimodal were performe...

Abstract— The WIGWAM research project (Wireless Gigabit with Advanced Multimedia) is aimed at designing a 1 Gbit/s system concept for the home/office, public access and high velocity scenarios. The cross-layer project covers PHY & MAC, integration into existing infrastructure and RF, BB and Dirty RF hardware and algorithm development. The current stage of the system concept is presented in this...