The effects of antegrade and antegrade with retrograde delivery of cardioplegic solution were evaluated in 60 patients who underwent myocardial revascularisation. All patients had triple vessel coronary artery disease and underwent revascularisation using arterial and vein grafts. Myocardial protection consisted of administration of the St.Thomas' Hospital cardioplegic solution, topical slushed...

BACKGROUND The pressure waveform of coronary sinus in human hearts has never been well described. Retrograde cardioplegia perfusion has become a popular method of myocardial protection in recent years, and identification of the pressure waveform of the coronary sinus might help intubate the coronary sinus in retrograde cardioplegia perfusion by differentiating it from that of the right atrium. ...

BACKGROUND To study the effect of nitecapone, a novel antioxidant, on cardiac neutrophil activation during cardiopulmonary bypass in patients. METHODS In a double-blind, placebo controlled trial, 30 male patients undergoing coronary artery bypass grafting were randomly assigned to control (crystalloid cardioplegia, n = 15) and nitecapone groups (cardioplegia supplemented with nitecapone, n = ...

I think we’re going to be really talking about Del Nido today, because of its observed effectiveness. It kind of went viral. A lot of surgeons wound up leaving Boston and going through other centers and taking it with them and it sort of spread like a little virus and other surgeons wanted this single-dose cardioplegia. The idea of operating uninterrupted sounds pretty appealing. Like Bob (Groo...

BACKGROUND The recent introduction of operations on a warm heart has prompted clinical reports on the usefulness of continuous blood cardioplegia, but no in-depth basic evaluation of continuous cardioplegia has been done. The cardioprotective effects of magnesium (Mg) and calcium (Ca) in continuous warm hyperkalemic crystalloid cardioplegic solutions were investigated in an isolated rat heart m...

OBJECTIVES To evaluate myocardial damage during coronary artery bypass grafting using three different intermittent cardioplegia and then measuring cTnI and CKMBm release. DESIGN AND METHODS Forty-two patients belonging to the hypothermic crystalloid (n = 16), hypothermic (n = 13), and normothermic blood (n = 13) groups were collected when removing the aortic cross-clamp (t = 0) and after 4, 1...

Background. We studied the effect of fast induction of cardiac arrest with denosine on myocardial bax and bcl-2 expression. Methods and Results. 40 elective CABG patients were allocated into two groups. The adenosine group (n = 20) received 250 mug/kg adenosine into the aortic root followed by blood potassium cardioplegia. The control group received potassium cardioplegia in blood. Bcl-2 and ba...