Vitamin B12 is an important cofactor in one-carbon metabolism whose dysregulation is associated with various clinical conditions. Indians have a high prevalence of B12 deficiency but little is known about the genetic determinants of circulating B12 concentrations in Indians. We performed a genome-wide association study in 1001 healthy participants in the Pune Maternal Nutrition Study (PMNS), re...

A combination of high folate with low vitamin B12 plasma status has been associated with cognitive impairment in a population exposed to mandatory folic acid fortification. The objective of the present study was to examine the interactions between plasma concentrations of folate and vitamin B12 markers in relation to cognitive performance in Norwegian elderly who were unexposed to mandatory or ...

Morphological and quantitative neutrophil abnormalities are common in the megaloblastic anemias of vitamin B12 and folic acid deficiency. Little is known, however, about the role of these vitamins in normal leukocyte function. Seven patients with megaloblastic bone marrows, four with vitamin B12 deficiency and three with folic acid deficiency, were studied to determine the effect, if any, of th...

BACKGROUND This study was designed to investigate the effects of the vitamins C and B12 on the regulation of human nasal ciliary beat frequency (CBF). METHODS Human nasal mucosa was removed endoscopically and nasal ciliated cell culture was established. Changes of CBF in response to different concentrations of vitamin C or vitamin B12 were quantified by using high-speed (240 frames per second...

Bg CHESTER GorruEB, KAM-SENG LAU, Louis R. \VASSERMAN AND VICTOR HERBERT T HIS COMMUNICATION reports the use of protein-coated charcoal iii rapid assays for: (1) intrinsic factor (IF), (2) unsaturated B12 binding capacity of gastric juice, (3) antibody to IF, and (4) serum unsaturated B12 binding capacity. The assays are based on the finding that charcoal precoated with a large molecule can ads...

BACKGROUND Proton pump inhibitors (PPIs) represent the most widely prescribed antisecretory agents, but their prolonged use, may influence iron and vitamin B12 status, which could have important implications for clinical practice. AIM We undertook this study aiming to investigate the association between PPIs use for 12 months and potential changes in iron and vitamin B12 status, as well as wh...

Long-term usage of antiepileptic drugs (AED) may lead to changes in serum vitamin B12 (B12) levels. Studies show that after sodium valproate prescription in epileptic patients, B12 concentrations increased.1 On the other hand, in the normal population, serum levels of B12 decreases with age.2 In the case of B12 deficiency, various hematologic, neurologic, and psychiatric clinical findings may b...

OBJECTIVES This study aims to assess the usefulness of serum holotranscobalamin (holoTC), the fraction of vitamin B12 that is available for tissue uptake, compared with total vitamin B12 in patients investigated for vitamin B12 disorders. METHODS Serum samples were randomly selected from 76 patients (48 females, 28 males; age range 12-69 years) referred to the Clinical Biochemistry Laboratory...

mean radioactivity in the serum was lower in both patients with pernicious anaemia and in control subjects, and the results in the patients with pernicious anaemia were more definitive. There was no significant difference between the results obtained with an Ekco scaler and those with an I.D.L. scaler. This is the simplest and most convenient method of measuring vitamin B12 absorption. It is su...