Article history: Received on: 05/10/2015 Revised on: 23/10/2015 Accepted on: 08/11/2015 Available online: 27/12/2015 This work, for the first time reports the optimization of recombinant human antithrombin (rhAT) production in Saccharomyces cerevisiae BY4741 using statistical experimental designs. Most applications of design of experiments (DoE) have concerned optimization of the composition of...

A quantitative analysis of a trans-generational, conversational corpus of Chintang (Tibeto-Burman) speakers with community-wide bilingualism in Nepali (Indo-European) reveals that children show more code-switching into Nepali than older speakers. This confirms earlier proposals in the literature that code-switching in bilingual children decreases when they gain proficiency in their dominant lan...

The interaction effect of eight operating factors on the degradation three organic dyes different structures (Cibacron green, methylene blue and methyl orange) has been studied. Effect had evaluated statistically using Plackett-Burman screening design which ex-tracted valuable information most important parameters their interactions. goodness model fit was checked by determination coefficient R...

In this work, a clean and simple magnetic solid-phase microextraction based on L-arginine modified dialdehyde starch nanocomposite was developed for the preconcentration determination of diclofenac in biological samples by UV–Vis Spectrophotometry. A Plackett–Burman experimental design used to evaluate influence effective parameters. Significant parameters were further optimized Central Composi...

The aim of this study was to evaluate the growth conditions affecting production of hosphatidylinositol-specific phospholipase-C (PIPLC) by Staphylococcus aureus ATCC 9144. A simple colorimetric method for direct estimation of phospholipids was adapted for rapid assaying of PIPLC. First phase of the study involved preliminary screening of nutritional and physical parameters. In the second phase...

AbstractInvestigation of alkaline protease production under different fermentation conditions using one factor at a time involving temperature, pH, incubation as well carbon and organic nitrogen sources .The results showed that the maximum activity (470U/ml) was obtained peptone 7.5 (g/L), glucose 5 pH 10, 24h 35oC. Further more, Two sequential statistical designs were used to optimize these ph...