Organic anion transporter 2 (Oat2 [SLC22A7]) is a multispecific organic anion transporter. Although several substrates of human Oat2 (hOat2) have been elucidated, a possible involvement of hOat2 in drug interaction is less defined. The purpose of this study was to investigate the interaction of theophylline with erythromycin mediated by hOat2 using a Xenopus laevis oocyte expression system. Whe...

Organic anion transporter 2 (Oat2 [SLC22A7]) is a multispecific organic anion transporter. Although several substrates of human Oat2 (hOat2) have been elucidated, a possible involvement of hOat2 in drug interaction is less defined. The purpose of this study was to investigate the interaction of theophylline with erythromycin mediated by hOat2 using a Xenopus laevis oocyte expression system. Whe...

The precise definition of a severe asthmatic exacerbation is an issue that presents difficulties. The term 'status asthmaticus' relates severity to outcome and has been used to define a severe asthmatic exacerbation that does not respond to and/or perilously delays the repetitive or continuous administration of short-acting inhaled beta(2)-adrenergic receptor agonists (SABA) in the emergency se...

TO THE EDITOR: The role of Toll-like receptor-7s (TLR7) in innate immunity against single-stranded RNA viruses is well established. Recently, our group found TLR7 agonists also relax guinea pig and human airway smooth muscle strips via production of nitric oxide (1, 2). Immunostaining identified extensive TLR7 expression on airway nerves, but none on smooth muscle; thus we hypothesized airway n...

Introduction Historically, plants have provided a source of inspiration for novel drug compounds, as plant-derived medicines have made large contributions to human health and well-being. Their role is two-fold in the development of new drugs: (1) they may become the basis for the development of new medicine, i.e. a natural blueprint for the development of new drugs; or (2) a phytomedicine to be...

Correspondence: *Inserm U408, Unité de Pneumologie de l'Hôpital Bichat, Paris, France. ** and Dept of Thoracic Medicine, National Heart and Lung Institute, London, UK. This issue of the European Respiratory Journal starts a series of short reviews based on a Satellite Meeting held during the European Respiratory Society Annual Meeting in Nice in October 1994. The symposium was supported by Byk ...

ALTHOUGH more than 100 yr have passed since anaphylaxis was first reported, clinicians continue to struggle with the definition and management of anaphylaxis. In a recent symposium organized by the National Institute of Allergy and Infectious Diseases (Bethesda, Maryland) and the Food Allergy and Anaphylaxis Network (Fairfax, Virginia), with representatives from the Center for Disease Control a...

ALTHOUGH more than 100 yr have passed since anaphylaxis was first reported, clinicians continue to struggle with the definition and management of anaphylaxis. In a recent symposium organized by the National Institute of Allergy and Infectious Diseases (Bethesda, Maryland) and the Food Allergy and Anaphylaxis Network (Fairfax, Virginia), with representatives from the Center for Disease Control a...

Agitation: 1. Violent motion. 2. Strong or tumultuous emotion. Management of the agitated patient is fast becoming an area of major breakthroughs for critical care medicine. To illustrate, Figure 1 shows the total number of articles found on MEDLINE using a combination of search words related to sedation and critical care. This crude survey demonstrates an exponential rise in activity surroundi...

ALTHOUGH more than 100 yr have passed since anaphylaxis was first reported, clinicians continue to struggle with the definition and management of anaphylaxis. In a recent symposium organized by the National Institute of Allergy and Infectious Diseases (Bethesda, Maryland) and the Food Allergy and Anaphylaxis Network (Fairfax, Virginia), with representatives from the Center for Disease Control a...