نتایج جستجو برای: bipolarity specifier

تعداد نتایج: 945  

Journal: :Current Biology 2009
David Vanneste Masatoshi Takagi Naoko Imamoto Isabelle Vernos

Spindle bipolarity relies on a fine balance of forces exerted by various molecular motors [1-4]. In most animal cells, spindle bipolarity requires sustained outward forces to push the spindle poles apart, an activity that is provided by Eg5, a conserved homotetrameric plus-end-directed kinesin that crosslinks and slides antiparallel microtubules apart [5]. These pushing forces are balanced by i...

Journal: :American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010
Francesco Casamassima Jie Huang Maurizio Fava Gary S Sachs Jordan W Smoller Giovanni B Cassano Lorenzo Lattanzi Jes Fagerness Jonathan P Stange Roy H Perlis

Variations in voltage-dependent calcium channel L-type, alpha 1C subunit (CACNA1C) gene have been associated with bipolar disorder in a recent meta-analysis of genome-wide association studies [Ferreira et al., 2008]. The impact of these variations on other psychiatric disorders has not been yet investigated. Caucasian non-Hispanic participants in the STAR*D study of treatment for depression for...

Journal: :The Journal of Cell Biology 2002
Helder Maiato Paula Sampaio Catarina L. Lemos John Findlay Mar Carmena William C. Earnshaw Claudio E. Sunkel

Multiple asters (MAST)/Orbit is a member of a new family of nonmotor microtubule-associated proteins that has been previously shown to be required for the organization of the mitotic spindle. Here we provide evidence that MAST/Orbit is required for functional kinetochore attachment, chromosome congression, and the maintenance of spindle bipolarity. In vivo analysis of Drosophila mast mutant emb...

Journal: :Journal of Linguistics 2022

This paper addresses the relation between two types of word order variation in stages Dutch: OV/VO historical Dutch and scrambling present-day Dutch. Information structural considerations influence both variation, we demonstrate by means a comprehensive corpus study that they have comparable pattern: given objects tend to appear earlier sentence than new objects. We infer from this are diachron...

Journal: :Syntax 2022

The Basque impersonal is a detransitivized construction where the internal argument only overt and external argument, although semantically present, does not have any morphological reflex. This article argues that, despite its intransitive shape, involves particular kind of Voice projection that we term defective. For case agreement, being defective means having no uninterpretable ϕ features Ca...

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