objective: this study aimed to evaluate the non-compliance rate in patients with bipolar i disorder (bid). methods: the patients admitted to iran psychiatric hospital who were diagnosed as a case of the first episode mania of bipolar i disorder (dsm-iv-tr) by 2 psychiatrists followed by one of them in a longitudinal, prospective and naturalistic study. in the follow-up early non-compliance/irre...

OBJECTIVE Little is known about the neurobiology of bipolar II disorder. While bipolar I disorder is associated with abnormally elevated activity in response to reward in the ventral striatum, a key component of reward circuitry, no studies have compared reward circuitry function in bipolar I and bipolar II disorders. Furthermore, associations among reward circuitry activity, reward sensitivity...

olanzapine is the frequently prescribed drug in children and adolescents with bipolar disorder, but unfortunately it has metabolic side-effects. on the other hand, in a number of melatonin studies on sleep cycle, regulation of metabolic abnormalities has been reported. therefore, we aimed to study effects of melatonin in reducing metabolic side-effects of olanzapine in 11-17 year-old patients w...

OBJECTIVE To compare the efficacy of intraturbinate monopolar cautery, bipolar cautery, high frequency monopolar and high frequency bipolar cautery in inferior turbinate hypertrophy. STUDY DESIGN Prospective randomized single blinded clinical study METHOD The study comprised of 80 patients divided in 4 groups each of 20 patients who underwent monopolar cautery, Bipolar cautery, high frequen...

Aims and method The mean delay for bipolar disorder diagnosis is 10 years. Identification of patients with previous hypomania is challenging, sometimes resulting in misdiagnosis. The aims of this study were: (a) to estimate the proportion of primary care patients with depression currently taking antidepressants who have undiagnosed bipolar disorder and (b) to compare a brief 3-item manic featur...

Changes in cortical thickness can be related to neuropsychiatric disorders and neurodegenerative processes. Previous studies have been conducted to characterize the pattern of changes in cortical thickness in several psychiatric diseases. The aim of the present study was to evaluate changes in cortical thickness with magnetic resonance imaging (MRI) in patients with bipolar disorder. Twenty-sev...

BACKGROUND The morbidity associated with bipolar disorder is, in part, responsible for repeated calls for improved detection and recognition. No such commentary exists for the improved detection of borderline personality disorder. Clinical experience suggests that it is as disabling as bipolar disorder, but no study has directly compared the two disorders. AIMS To compare the levels of psycho...

Carbamazepine (CBZ) has long been a therapeutic option for bipolar disorder. Carbamazepine extended-release capsules (CBZ-ERC) are a recent formulation of CBZ approved by the US Food and Drug Administration in 2004 for the treatment of acute manic and mixed episodes associated with bipolar I disorder. This new formulation was developed to improve dosing convenience and decrease daily fluctuatio...

BACKGROUND Cognitive deficits associated with mood disorders, especially bipolar disorder, have been the focus of limited systematic investigation. METHODS We tested 35 bipolar (21 in depressed state and 14 in mixed or manic state) and 58 nonbipolar depressed consecutively admitted young adult inpatients and 51 matched healthy individuals on the Cambridge Neuropsychological Test Automated Bat...

This MRI study examined the morphology of the olfactory sulcus, a potential marker of early neurodevelopment in 26 patients with bipolar I disorder and 24 matched controls. Bipolar patients had significantly shallower olfactory sulci bilaterally compared to controls, suggesting that neurodevelopmental abnormalities contribute to the neurobiology of bipolar disorder.