INTRODUCTION. Bacterial infection in cirrhotic patients is a severe complication that requires early recognition and specific therapeutic care. MATERIAL AND METHODS. In this review the various aspects of diagnosis and management of infections that may impact survival in cirrhosis are analyzed. RESULTS. Active search for infections allows early detection and its treatment with suitable antibioti...

CD8 knockout mice depleted of natural killer (NK) cells by treatment with anti-asialoGM1 (CD8KO/alphaAsGM1 mice) are resistant to injury caused by cecal ligation and puncture (CLP). However, CLP-induced injury is complex. Potential sources of injury include bacterial dissemination, cecal ischemia, and translocation of bacterial toxins. We treated wild-type and CD8KO/alphaAsGM1 mice with imipene...

BACKGROUND Nod-like receptor family, pyrin domain containing 3 (NLRP3) is an important cytosolic sensor of cellular stress and infection. Once activated, NLRP3 forms a multiprotein complex (inflammasome) that triggers the maturation and secretion of interleukin (IL)-1β and IL-18. We aimed to define the consequences of NLRP3 induction, utilizing exogenous adenosine triphosphate (ATP) as an infla...

Spacecraft-associated spores and four non-spore-forming bacterial isolates were prepared in Atacama Desert soil suspensions and tested both in solution and in a desiccated state to elucidate the shadowing effect of soil particulates on bacterial survival under simulated Martian atmospheric and UV irradiation conditions. All non-spore-forming cells that were prepared in nutrient-depleted, 0.2-mi...

Biliary obstruction in the setting of hepatic bacterial infection has great morbidity and mortality. We developed a novel murine model to examine the effect of biliary obstruction on the clearance of hepatic Escherichia coli infection. This model may allow us to test the hypothesis that biliary obstruction itself adversely affects clearance of hepatic infections even if the bacteria are introdu...

Microcosm studies were performed to evaluate the survival of Escherichia coli, Salmonella paratyphi and Vibrio parahaemolyticus in water and sediment collected from the freshwater region of Vembanad Lake (9'35 °N 76'25 °E) along the south west coast of India. All three test microorganisms showed significantly (p < 0.01) higher survival in sediment compared to overlying water. The survival in di...

BACKGROUND Ruptured sinus of Valsalva aneurysm is a rare cardiac anomaly and long-term survival after surgical treatment is not well established. This study was designed to investigate the determinants of long-term survival after repair of ruptured sinus of Valsalva aneurysm. METHODS From April 1978 to April 1996, 53 patients underwent operation for ruptured sinus of Valsalva aneurysm. The in...

Abstract Background Bacterial translocation is considered the pathophysiological hallmark in development of spontaneous bacterial peritonitis (SBP). Prokinetics can increase gastrointestinal (GIT) motility, reduce small bowel transit time, decrease translocation, and possibility SBP. The aim this work was to compare effectiveness safety itopride norfloxacin versus only secondary prophylaxis for...

Methicillin resistant Staphylococcus aureus (MRSA) isolates have become more prevalent among athletes. The objective of this study is to examine the survival S. on synthetic turf systems and natural turfgrass under varying environmental conditions evaluate effectiveness various control agents applied turf. Under non-extreme temperature very limited light conditions, less than 4% survived both f...