background: to date, studies on methadone overdose in adults have not been ‎reported in iran. hence, this study was performed to determine the frequency of ‎methadone overdose and its associated complications in baharloo hospital of tehran ‎between august 2011 and august 2012.‎ methods: this cross-sectional study was done on 390 cases. all patients with ‎methadone overdoses and positive urine s...

the effect of opium addiction on the appearance of different types of arrhythmias after acute myocardial infarction (ami) has been assessed in few studies. this study is aimed to determine the effect of opium on post-mi arrhythmia and also to address the differences in the appearance of different types of arrhythmias after ami between opium addicted and non-addicted patients. in this comparativ...

objective(s) in this study, effects of chronic administration of oral natural honey against ischemia/reperfusion (i/r)-  induced cardiac arrhythmias were investigated in isolated rat heart. materials and methods male wistar rats were divided into four groups (n= 10-14 rats in each group) and fed with natural honey (1%, 2% and 4% dissolved in the drinking water) for 45 days except for the contro...

in this study, it was surveyed to know whether an oral single dose of oleuropein could mimic the cardiac preconditioning in rats’ hearts or whether its prolonged oral administration could protect the heart against the aconitine-induced arrhythmia in rats. eighty male wistar rats were divided into two series (n = 8 in each group). in the first series, all groups (except the control (con) group) ...

Depressed cardiac contractility is central to many forms of cardiac disease and reflects the heart’s inability to generate adequate force despite being provided physiological activator calcium and chamber load. Yet, successful methods to enhance cardiac contractility have remained elusive. Agents such as dobutamine or milrinone that work through the -receptor–cAMP–protein kinase A pathway are u...

OBJECTIVE To compare the safety and effectiveness of long-acting β-antagonists (LABA), long-acting antimuscarinic agents (LAMA) and inhaled corticosteroids (ICS) for managing chronic obstructive pulmonary disease (COPD). SETTING Systematic review and network meta-analysis (NMA). PARTICIPANTS 208 randomised clinical trials (RCTs) including 134,692 adults with COPD. INTERVENTIONS LABA, LAMA...

Inotropes have been fundamental to resuscitation of acute cardiogenic shock for decades. Heart failure and cardiogenic shock, in severe cases, are syndromes characterized in many patients by a reduction in myocardial contractile force. While inotropes successfully increase cardiac output, their use has been plagued by excessive mortality due to increased tachycardia and myocardial oxygen consum...

BACKGROUND/AIM To investigate the influence of thiopental (85 mg/kg, intraperitoneally (ip)), and ketamine+xylazine (ketamine 75 mg/kg and xylazine 8 mg/kg, ip) anesthesia on the incidence and duration of ischemia/reperfusion-induced arrhythmias. MATERIALS AND METHODS Myocardial ischemia was induced by a 6-min ligation of the left anterior descending coronary artery, followed by a 6-min reper...

Complementary and alternative medical (CAM) therapies are commonly used by patients for the treatment of medical conditions spanning the full spectrum of severity and chronicity. The use of alternative remedies, both herbal and others, for conditions lacking effective medical treatment, is on the increase. Included within this categorization, arrhythmic disease-absent effective catheter-based t...