radioiodine therapy is the safest, simplest, least expensive and most effective method for treatment of hyperthyroidism. the method employed in this research was a systematic bibliographic review, in which only valid studies or the clinically detailed enough open-labeled studies using validated scales were used. iodine-131 (i-131) acts by the destructive effect of short-range beta radiation on ...

Graves' disease (GD) accounts for a large proportion of pediatric hyperthyroidism, and the first-line treatment is antithyroid drug (ATD) therapy. Methimazole (MMI) is effective in most patients but is associated with significant adverse events (AEs). We reviewed the medical records of GD patients (n = 56) with onset age of <15 yr and investigated the relationship between MMI dose and AEs. The ...

Antithyroid drugs (ATDs) induced agranulocytosis is a rare but life threatening condition. We report a 29 years Filipino female diagnosed as having hyperthyroidism with normal base line blood counts, liver and renal profile. She was started on maximum 60 mg (20mg TID) oral dose of carbimazole since one month by her treating physician. Exactly after one month of treatment she presented to emerge...

BACKGROUND/AIMS Treatments for Graves' disease (GD) in children and adolescents include oral antithyroid drugs (ATDs), near total thyroidectomy, and radioactive iodine (RAI). ATDs remain the preferred choice in this age group, but because persistent remission occurs in 30% of cases, RAI is becoming a common option for definitive therapy. METHODS We performed a review of 65 medical records of ...

Context Accurate measurements of circulating hormones is essential for the practice of endocrinology. Immunometric assays employing the streptavidin-biotin system are widely used to measure hormones. However, these assays are susceptible to interference in patients taking biotin supplementations. This interference could mimic a coherent hormone profile, leading to misdiagnosis and unnecessary t...

IT IS now accepted that the tendon reflex is prolonged in patients with hypothyroidism. Chaney (1924) was the first worker to record the Achilles tendon reflex and prove what had previously been detected clinically. Since then several systems have been devised for recording the ankle jerk (Lambert, Underdahl, Beckett, and Mederos, 1951; Lawson, 1958; Gilson, 1959; Sharpe, 1961; Smart and Robson...

A 32-year old female patient was hospitalized in a referral hospital with fever, diarrhea, seizures and altered sensorium. On physical examination, patient was febrile with tachycardia. Suspecting the diagnosis of thyroid storm clinically, the patient was started on aggressive antithyroid treatment after which she showed marked clinical improvement.

Context. To report a patient with hyperthyroidism who developed concurrent occurrence of agranulocytosis and severe hepatotoxicity after taking methimazole (MMI). Case. A 51-year-old Chinese male was diagnosed as hyperthyroidism with normal white blood count and liver function. After 4 weeks' treatment with MMI 20 mg/d, it developed to agranulocytosis and severe cholestatic hepatotoxicity. The ...