Mycophenolic acid (MPA) is a fungal metabolite possessing antiviral, antifungal, antibacterial, antitumor and anti-psoriasis activities. It is being used as an immunosuppressive agent in kidney, heart and liver transplantation patients. In the presence of MPA, the proliferation of the B and T lymphocytes is inhibited. The MPaB and MPaE genes reside in a 25 kb gene cluster in t...

The genus Myrciaria occurs in various Brazilian biomes. Its species contains several active components, including phenolic compounds, such as tannins, flavonoids, ellagic acid and anthocyanins. Biological activities reported for Myrciaria fruits and leaf and bark extracts include antioxidant, antibacterial and antifungal effects. This work aims to provide an overview of the active compounds of ...

Seven new polyoxygenated steroids (1-7) were isolated together with seven known analogues (8-14) from the South China Sea soft coral, Sarcophyton sp. The structures of the new compounds were identified on the basis of extensive spectroscopic analysis and comparison with reported data. All the steroids are characterized with 3β,5α,6β-hydroxy moiety, displaying carbon skeletons of cholestane, erg...

Microorganisms have provided a bounty of bioactive secondary metabolites with very exciting biological activities such as antibacterial, antifungal antiviral, and anticancer, etc. The present study aims at the optimization of culture conditions for improved antimicrobial production of Paenibacillus elgii obtained from Wayanad forest of Western Ghats region of Kerala, India. A bacterial strain i...

Lyngbya spp. is one of the most efficient groups of secondary metabolite producers and is very important from pharmaceutical point of view. Among its various species, majuscula is the major producers of commercially important biomolecules. Several species have been isolated and screened from the marine in the past decades. Although the chance of isolating a novel Lyngbya strain from a marine ha...

Many plants produce low-molecular-weight compounds which inhibit the growth of phytopathogenic fungi in vitro. These compounds may be preformed inhibitors that are present constitutively in healthy plants (also known as phytoanticipins), or they may be synthesized in response to pathogen attack (phytoalexins). Successful pathogens must be able to circumvent or overcome these antifungal defenses...

Marine bioresources are a valuable source of bioactive compounds with industrial and nutraceutical potential. Numerous clinical trials evaluating novel chemotherapeutic agents derived from marine sources have revealed novel mechanisms of action. Recently, marine-derived bioactive peptides have attracted attention owing to their numerous beneficial effects. Moreover, several studies have reporte...

Voriconazole is a new triazole antifungal agent with potent, wide-spectrum activity. Its pharmacokinetics and metabolism have been studied in mouse, rat, rabbit, dog, guinea pig, and humans after single and multiple administration by both oral and intravenous routes. Absorption of voriconazole is essentially complete in all species. The elimination of voriconazole is characterized by non-linear...

Investigation of the chemical profile of the industrially important black filamentous fungus Aspergillus aculeatus by UHPLC-DAD-HRMS and subsequent dereplication has led to the discovery of several novel compounds. Isolation and extensive 1D and 2D NMR spectroscopic analyses allowed for structural elucidation of a dioxomorpholine, a unique okaramine, an aflavinine and three novel structures of ...

Introduction Afzelin is a glycosyloxyflavone that kaempferol attached to an alpha-L-rhamnosyl residue at position 3 via glycosidic linkage. It has role as plant metabolite, antimicrobial (Antibacterial and antifungal) agent anti-inflammatory agent. glycosyloxyflavone, trihydroxyflavone monosaccharide derivative. In this work, we determined the anticholinergic, antiepileptic, antidiabetic, anti-...