Some drugs have low bioavailability due to their poor aqueous solubility and/or slowdissolution rate in biological fluids. Stiripentol (STP) is a novel anticonvulsant drug that isstructurally unrelated to the currently available antiepileptics. It has poor aqueous solubilityand its solubility has to be enhanced accordingly. Polyethyleneglycol 6000 (PEG-6000) iscommonly utilized as a hydrophilic...

Objective: GABAergic system is a target for various groups of medications including sedatives, anxiolytics, muscle relaxants, antidepressants and antiepileptics. Several foods or food ingredients are able to affect the by inhibition γ-aminobutyric acid (GABA) degrading enzymes GABA-transaminase succinate semialdehyde dehydrogenase. The purpose this study investigate inhibitory effects tea (Came...

Polycystic kidney disease (PKD) is the most common hereditary disorder of kidneys. In adults, PKD1 gene mutation almost always signifies its subtype, autosomal dominant polycystic (ADPKD), or adult disease. ADPKD a multisystemic giving rise to renal and extra-renal manifestations. The shutdown feared complication while development intracranial aneurysms considered lethal feature. This can be at...

Active substances detected in surface water Hungary today include pain and anti-inflammatory agents antiepileptics, as wastewater treatment mechanisms cannot remove these micropollutants. The aim of our research is to detect residues four pain-killer drugs—naproxen, nimesulide, diclofenac, ibuprofen—and an anti-epileptic drug—carbamazepine—in samples we collected (n = 8) from the Danube. Our we...

Though we are approaching the end of second wave COVID pandemic, still unrevealing various presentation this viral infection can result in. There few cases reported to have anti NMDA autoimmune encephalitis associated with COVID-19 or MIS-C. Here reporting one its variants that was anti-GABAB receptor infection. We a 9 years old female child who known case seizure disorder and on regular medica...

Valproic acid and meropenem is generally co-administrated in neurosurgical cases. Meropenem potentially decreases thevalproic position, which may beget perioperative turn like seizure. Such serious adverse effect through potential interactionshould be taken seriously made aware by clinicians. Among various neurological emergencies status epilepticus one ofthe most important as it progresses, th...

Background: Adverse drug reactions (ADRs) have a high impact on morbidity and mortality of the population, becoming public health issue. Studying publishing about these is referred as pharmacovigilance.Objective: To describe compare adverse produced by drugs nervous system action (CNS-D) neurological ADRs systemic (Sys-D). further develop need reporting reactions. Methods: An observational, cro...

Orphenadrine is an anticholinergic drug used in the treatment of Parkinson's disease, and is also known to exert nonspecific antagonistic activity at the phencyclidine binding site of the N-methyl-D-aspartate (NMDA) receptor. The aim of this study was to assess the anticonvulsant properties of orphenadrine and to evaluate its effect on the anticonvulsant activity of antiepileptic drugs against ...