نتایج جستجو برای: and ns5a proteins

تعداد نتایج: 16874701  

2013
Tatiana Kuznetsova Tatjana Tallo Vadim Brjalin Irina Reshetnjak Riina Salupere Ljudmilla Priimagi Olga Katargina Maria Smirnova Juris Jansons Valentina Tefanova

BACKGROUND A substantial proportion of hepatitis C virus (HCV)-1b infected patients do not response to pegylated interferon-α plus ribavirin (PegIFNα/RBV) combination therapy that was partially associated with mutations in the non-structural 5A (NS5A) protein. OBJECTIVES Analysis of NS5A polymorphisms in HCV genotype 1b pre-treatment serum samples from Estonian patients and their effect on th...

2018
Yuki Haga Tatsuo Kanda Shin Yasui Masato Nakamura Yoshihiko Ooka Koji Takahashi Shuang Wu Shingo Nakamoto Makoto Arai Tetsuhiro Chiba Hitoshi Maruyama Osamu Yokosuka Nobuo Takada Mitsuhiko Moriyama Fumio Imazeki Naoya Kato

Background Interferon-free treatment results in higher sustained virologic response (SVR) rates, with no serious adverse events in hepatitis C virus (HCV)-infected patients. However, in some patients with treatment-failure in HCV NS5A inhibitor-including interferon-free regimens, the treatment-emergent HCV NS5A resistance-associated variants (RAVs), which are resistant to interferon-free retrea...

Journal: :Journal of virology 2005
Nicole Appel Ulrike Herian Ralf Bartenschlager

Studies of Hepatitis C virus (HCV) RNA replication have become possible with the development of subgenomic replicons. This system allows the functional analysis of the essential components of the viral replication complex, which so far are poorly defined. In the present study we wanted to investigate whether lethal mutations in HCV nonstructural genes can be rescued by trans-complementation. Th...

2015
Hirotake Kasai Kunihiro Kawakami Hiromasa Yokoe Kentaro Yoshimura Masanori Matsuda Jun Yasumoto Shinya Maekawa Atsuya Yamashita Tomohisa Tanaka Masanori Ikeda Nobuyuki Kato Toru Okamoto Yoshiharu Matsuura Naoya Sakamoto Nobuyuki Enomoto Sen Takeda Hideki Fujii Masayoshi Tsubuki Masami Kusunoki Kohji Moriishi

The chaperone system is known to be exploited by viruses for their replication. In the present study, we identified the cochaperone FKBP6 as a host factor required for hepatitis C virus (HCV) replication. FKBP6 is a peptidyl prolyl cis-trans isomerase with three domains of the tetratricopeptide repeat (TPR), but lacks FK-506 binding ability. FKBP6 interacted with HCV nonstructural protein 5A (N...

2014
Chao-Kuen Lai Vikas Saxena Chung-Hsin Tseng King-Song Jeng Michinori Kohara Michael M. C. Lai

Nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) serves dual functions in viral RNA replication and virus assembly. Here, we demonstrate that HCV replication complex along with NS5A and Core protein was transported to the lipid droplet (LD) through microtubules, and NS5A-Core complexes were then transported from LD through early-to-late endosomes to the plasma membrane via microtubule...

Journal: :The Kobe journal of medical sciences 2004
Rachmat Hidajat Motoko Nagano-Fujii Lin Deng Hak Hotta

Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) has versatile functions and has been implicated in viral pathogenesis, including interferon (IFN) resistance and hepatocarcinogenesis. It has been reported that NS5A is cleaved into a few fragments by a caspase(s) or caspase-like enzyme(s) under certain conditions. Two cleavage sites have been mapped to the Asp residues at positions 154 an...

Journal: :Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2015
Andreas Walker Holger Siemann Svenja Groten R Stefan Ross Norbert Scherbaum Jörg Timm

BACKGROUND People who inject drugs (PWID) are the most important risk group for incident Hepatitis C virus (HCV) infection. In PWID in Europe HCV genotype 3a is highly prevalent. Unfortunately, many of the recently developed directly acting antiviral drugs against HCV (DAAs) are suboptimal for treatment of this genotype. Detection of resistance-associated variants (RAV) in genotype 3a may help ...

Journal: :Cancer research 2009
Santanu Raychaudhuri Vanessa Fontanes Bhaswati Barat Asim Dasgupta

Hepatitis C virus (HCV) causes chronic infection in humans leading to liver cirrhosis and hepatocellular carcinoma. rRNA transcription, catalyzed by RNA polymerase I (Pol I), plays a critical role in ribosome biogenesis, and changes in Pol I transcription rate are associated with profound alterations in the growth rate of the cell. Because rRNA synthesis is intimately linked to cell growth and ...

2012
Israr-ul H. Ansari Rob Striker

Hepatitis C virus (HCV) is susceptible to cyclosporine (CsA) and other cyclophilin (CypA) inhibitors, but the genetic basis of susceptibility is controversial. Whether genetic variation in NS5A alters cell culture susceptibility of HCV to CypA inhibition is unclear. We constructed replicons containing NS5A chimeras from genotypes 1a, 2a and 4a to test how variation in carboxy terminal regions o...

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