نتایج جستجو برای: anaplastic lymphoma kinase

تعداد نتایج: 333698  

Journal: :Voprosy gematologii/onkologii i immunopatologii v pediatrii 2023

Anaplastic large cell lymphoma (ALCL) expressing the anaplastic kinase (ALK) (ALK + ALCL) is a rare type of which comprises 10-15% all non-Hodgkin lymphomas in children and 2–3% young adults. Relapsed/refractory disease occurs even more rarely (25–40% cases). There as yet no standard treatment for relapsed/refractory ALK ALCL. Patients with ALCL usually present at advanced stages extranodal inv...

Journal: :Mechanisms of Development 2009
Min-A. Choi Wern-Joo Sohn Hye-In Jung Hong-In Shin Sang Gyu Lee Han-Sung Jung Jae-Young Kim

the embryo, consistent with a shared origin of these cell-types. We also present evidence that iridophore precursors are likely to also have glial potential. Finally, we engineered constitutively active form of ltk gene by analogy with oncogenic gene nucleophosmin-anaplastic lymphoma kinase, and examine the results from experiments asking what happens to NCCs with constitutively active Ltk sign...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2015
Rani E George

Bellini and colleagues demonstrate the importance of next-generation sequencing to uncover subclonal anaplastic lymphoma kinase (ALK) mutations in neuroblastoma. Although the significance of these subclonal aberrations is not yet understood, deep sequencing could identify patients whose tumors may respond to ALK inhibitors.

2012
Nir Peled Marileila Varella-Garcia

Journal of Thoracic Oncology • Volume 7, Number 9, September 2012 The echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) gene fusion occurs in 2% to 7% of non–small-cell lung cancer (NSCLC) cases and is typically identified by Vysis ALK Break-Apart fluorescent in situ hybridization (FISH) assay. Tumors expressing this fusion respond to treatment using crizoti...

Journal: :Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2012
Kazuko Sakai Isamu Okamoto Ken Takezawa Tomonori Hirashima Hiroyasu Kaneda Masayuki Takeda Kazuko Matsumoto Hideharu Kimura Yoshihiko Fujita Kazuhiko Nakagawa Tokuzo Arao Kazuto Nishio

INTRODUCTION The presence of the transforming fusion gene echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) in non-small-cell lung cancer (NSCLC) is a predictive marker for the efficacy of anaplastic lymphoma kinase inhibitors. However, the currently available assays for the detection of the different variants of EML4-ALK have limitations. METHODS We dev...

2015
Shuiqing Wu Ran Xu Qi Wan Xuan Zhu Lei Zhang Hongyi Jiang Xiaokun Zhao

OBJECTIVE To assess the value of anaplastic lymphoma kinase for the diagnosis of inflammatory myofibroblastic tumours using a comprehensive meta-analysis. METHODS We searched the related literature using electronic databases and manual searches. Approximately 454 cases from several countries were included in this analysis. The quality of studies included was assessed by QUADAS (quality assess...

Journal: :Blood 2010
Javeed Iqbal Dennis D Weisenburger Timothy C Greiner Julie M Vose Timothy McKeithan Can Kucuk Huimin Geng Karen Deffenbacher Lynette Smith Karen Dybkaer Shigeo Nakamura Masao Seto Jan Delabie Francoise Berger Florence Loong Wing Y Au Young-Hyeh Ko Ivy Sng James Olen Armitage Wing C Chan

Peripheral T-cell lymphoma (PTCL) is often challenging to diagnose and classify. Gene expression profiling was performed on 144 cases of PTCL and natural killer cell lymphoma and robust molecular classifiers were constructed for angioimmunoblastic T-cell lymphoma (AITL), anaplastic lymphoma kinase-positive (ALK(+)) anaplastic large-cell lymphoma (ALCL), and adult T-cell leukemia/lymphoma. PTCL-...

Journal: :Blood 2010
Norbert Schmitz Lorenz Trümper Marita Ziepert Maike Nickelsen Anthony D Ho Bernd Metzner Norma Peter Markus Loeffler Andreas Rosenwald Michael Pfreundschuh

To evaluate outcome and prognosis of patients with T-cell lymphoma we analyzed 343 patients treated within trials of the German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL). Two hundred eighty-nine patients belonged to 1 of the 4 major T-cell lymphoma subtypes: anaplastic large cell lymphoma (ALCL), anaplastic large cell lymphoma kinase (ALK)-positive (n = 78); ALCL, ALK-negative (n = 1...

Journal: :Frontiers in bioscience 2015
Claudia Voena Silvia Peola Roberto Chiarle

Twenty years ago anaplastic lymphoma kinase (ALK) was discovered in anaplastic large cell lymphoma (ALCL), but the interest in ALK as an oncogene grew only in recent years when ALK rearrangements were reported as recurrent genetic lesions in lung carcinoma and activating single point mutations were described in neuroblastoma. In this review we will describe the main features of ALK-rearranged s...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید