s of papers 23 with ascites syndrome, reciprocal F1 crosses of the RES and SUS lines were produced. One objective of this multidisciplinary trial was to determine the effects of hypobaric hypoxia on gut development in the pure-line RES, pure-line SUS, and the reciprocal F1 crosses (RS, SR). Four hundred and eighty vaccinated, pedigreed broiler chickens (40 groups of 12 birds) were randomly assi...

Acute exposure to high altitude hypoxia is known to decrease physical performance. The exercise performance increases during moderate altitude training (2000-3000 m) but benefits are overshadowed by adverse effect associated with hypoxia. Therefore, the study was designed to address whether low altitude of 1200 m could increase exercise performance without any adverse effects and a correlation ...

The study of healthy human volunteers ascending to high altitude provides a robust model of the complex physiological interplay that emulates human adaptation to hypoxaemia in clinical conditions. Nitric oxide (NO) metabolism may play an important role in both adaptation to high altitude and response to hypoxaemia during critical illness at sea level. Circulating nitrate and nitrite concentrati...

Rapid ascent to high altitude causes illness and fatigue, and there is a demand for effective acute treatments to alleviate such effects. We hypothesized that increased oxygen delivery to the tissue using a combination of a hypertensive agent and an endothelin receptor A antagonist drugs would limit exercise-induced fatigue at simulated high altitude. Our data showed that the combination of 0.1...

OBJECTIVES High-altitude hypoxia, or decreased oxygen levels caused by low barometric pressure, challenges the ability of humans to live and reproduce. Despite these challenges, human populations have lived on the Andean Altiplano and the Tibetan Plateau for millennia and exhibit unique circulatory, respiratory, and hematological adaptations to life at high altitude. We and others have identifi...

The number of people travelling to the high altitude regions, especially South America, Nepal, and India, has risen enormously in the past 10 years. Without special climbing ability these trekkers can be exposed to altitudes they will not have encountered in their home countries. For example, the height of Everest base camp is 5500 m whereas the top of Mount Blanc, the highest mountain in the A...

Emerging trends of underutilization of high altitude medicinal plants by Indian phytopharmaceutical industry suggest that therapeutic potential of these species has been exploited to a very less extent despite availability of rich traditional knowledge and also greater possibilities of offering novel bioactive compounds. According to a recent estimate only 20% high altitude medicinal plants ava...

Little is known with regard to how acute and chronic high altitude exposure effects immune function. Hypoxia is an environmental stressor that is known to elicit alterations in both the autonomic nervous system and endocrine function. Alterations in these systems can have an immediate as well as a longer lasting impact on immune function. Studies from the summit of Pikes Peak (4300 m) have indi...

Acute exposure to high altitude, which is defined as > 2500 m above sea level, is well-known to be associated with significant alterations to the cardiovascular system, with reductions in atmospheric pressure, oxygen pressure resulting in acute hypoxia, increased myocardial work, increased epinephrine release , and increased pulmonary artery pressures. 1) However, the effects of moderate altitu...

High altitude acclimatization produces a suite of physiological changes that might support an improved athletic performance at low altitude and thus lead to the strategy of athletic training at high altitude. Although there is substantial literature on high altitude physiology in humans, there are few studies on horses. Our interest in the physiological responses to high altitude in equids has ...