When retinoic acid-primed F9 cells are allowed to aggregate, they form embryoid bodies with an outer layer of (&agr;)-fetoprotein-producing visceral endoderm cells and an internal cavity. I show that maturation of the visceral endoderm is dependent on the size of F9 aggregates. Size fractionation of aggregates of retinoic acid-primed F9 cells on Percoll density gradients revealed that only aggr...

Background: Most patients with hepatocellular carcinoma (HCC) are diagnosed at late stages despite of improvement screening programs and lack effective diagnostic methods for cases preclinical HCC leads to a low rate early detection. Aldo-keto reductase family 1 member B10 (AKR1B10) is associated several types cancer. However, our knowledge, the significance AKR1B10 measurement in stage has poo...