Guanosine diphosphate D-mannuronic acid and guanosine diphosphate L-guluronic acid were isolated from the marine brown alga, Fucus gardneri Silva. These uronic acid nucleotides, reported to occur for the first time in living cells, are considered to be the precursors for the biosynthesis of alginic acid which constitutes about 18% of this alga. A mixture of 3 moles of the two uronic acid nucleo...