SUMMARY A new murine oncogenic virus has been isolated which induces solid lymphoid tumors within a short latent period. A unique feature of this disease is the lack of thymic involvement. Thymic-independent tumor induction distin guishes this virus from the other experimental murine lymphoid leukemia viruses. In addition, massive meningeal tumors, a myelocytic leukemoid reaction, and no eviden...

In an attempt to lay a sound foundation for understand ing the therapeutic effectiveness of glucocorticoids in the treatment of hematological cancers, we have studied glucocorticoid receptors and sensitivity to glucocorticoids in vitro in the malignant cells from 56 patients with leuke mia and lymphoma and in peripheral lymphocytes from normal donors. In contrast to several previous studies in ...

hypercalcemia complicating malignancy is a rare complication in pediatric age group. in this article, we present a case with acute lymphoblastic leukemia presenting as severe hypercalcemia. a 10 years old girl presented with an acute onset of fever, nausea, vomiting, loss of weight, costovertebral pain and frequency. she was admitted with a presumptive diagnosis of acute pyelonephritis. her exa...

background: acute myeloid leukemia (aml) with translocation (3,3) is a form of aml that may present de novo or may arise from a previous myelodysplastic syndrome. it is often associated with normal or elevated peripheral blood platelet count and increased bone marrow megakaryocytes with associated multi lineage dysplasia. a subset of patients present with hepatosplenomegaly while a few cases ha...

introduction: gtpase regulator associated with focal adhesion kinase (graf) is a recently identified gtpase activating protein that has the tumor suppressor properties. however, the expression level of graf in leukemia had received less attention. the main purpose of this research was the evaluating of the expression level of graf in patients with acute myeloid leukemia (aml). materials and met...