نتایج جستجو برای: abcg1 abcg5 pyy 3

تعداد نتایج: 1812486  

Journal: :Journal of lipid research 2004
Li-Ping Duan Helen H Wang David Q-H Wang

In the present study, we investigated whether intestinal sterol efflux transporters Abcg5 and Abcg8 play a major role in determining variations in cholesterol (Ch) absorption efficiency, and we compared the physiological functions of the duodenal, jejunal, and ileal Abcg5 and Abcg8 on the absorption of Ch and sitostanol in inbred mice challenged with various amounts of Ch, sitostanol, hydrophil...

2014
Fang Liu Wei Wang Yan Xu Yu Wang Lian-Feng Chen Quan Fang Xiao-Wei Yan

ATP-binding cassette transporter G1 (ABCG1) is a transmembrane cholesterol transporter involved in macrophage sterol homeostasis, reverse cholesterol transport (RCT), and atherosclerosis. The role of ABCG1 in atherosclerosis remains controversial, especially in animal models. Our previous study showed that single nucleotide polymorphism rs57137919 (-367G>A) in the ABCG1 promoter region was asso...

Journal: :IUPHAR/BPS guide to pharmacology CITE 2023

Neuropeptide Y (NPY) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Receptors [158]) are activated endogenous peptides neuropeptide Y, Y-(3-36), peptide YY, PYY-(3-36) and pancreatic polypeptide (PP). The receptor originally identified Y3 has been CXCR4 chemokine recepter (originally named LESTR, [139]). y6 is a functional gene product in mouse, absent rat, but contains fram...

2016
Yi-Hsien Chen Patrick J. Cimino Jingqin Luo Sonika Dahiya David H. Gutmann

The overall survival for adults with malignant glioma (glioblastoma) remains poor despite advances in radiation and chemotherapy. One of the mechanisms by which cancer cells develop relative resistance to treatment is through de-regulation of endoplasmic reticulum (ER) homeostasis. We have recently shown that ABCG1, an ATP-binding cassette transporter, maintains ER homeostasis and suppresses ER...

Journal: :Molecular medicine reports 2014
Ge Wu Gui-Bin Li Ming Yao Dong-Qing Zhang Bin Dai Chuan-Jing Ju Ming Han

ATP-binding cassette sub-family G member 5 (ABCG5) and ABCG8 are members of an ATP-binding cassette transporter superfamily. ABCG5 and ABCG8 variants affected serum levels of cholesterol and were considered as risk factors for coronary heart disease (CHD). The present control study analyzed ABCG5 and ABCG8 variants in a population for association with the risk of CHD. A total of 417 CHD patient...

2008
Feng Lian Piao Kuichang Yuan Guang Yi Bai Jeong Hee Han Woo Hyun Park Suhn Hee Kim

Neuropeptide Y (NPY) receptors are present in cardiac membranes. However, its physiological roles in the heart are not clear. The aim of this study was to define the direct effects of pancreatic polypeptide (PP) on atrial dynamics and atrial natriuretic peptide (ANP) release in perfused beating atria. Pancreatic polypeptides, a NPY Y(4) receptor agonist, decreased atrial contractility but was n...

Journal: :Circulation 2006
Snehal U Naik Xun Wang Jaqueline S Da Silva Michael Jaye Colin H Macphee Muredach P Reilly Jeffrey T Billheimer George H Rothblat Daniel J Rader

BACKGROUND Liver X receptors (LXRs) are ligand-activated transcription factors involved in the control of lipid metabolism and inflammation. Synthetic LXR agonists have been shown to inhibit the progression of atherosclerosis in mice, but the mechanism is uncertain. LXR agonism upregulates the genes encoding ATP binding cassette transporters A1 (ABCA1) and G1 (ABCG1) in macrophages, thus promot...

Journal: :The Yale Journal of Biology and Medicine 1992
A. P. Vukasin G. H. Ballantyne O. Nilsson A. J. Bilchik T. E. Adrian I. M. Modlin

Peptide YY (PYY) and enteroglucagon are produced by endocrine cells of the colonic mucosa. PYY inhibits upper gastrointestinal motility, and enteroglucagon is trophic for small bowel mucosa. Adaptive increase in the production and release of these peptides may improve functional results after colorectal resections. We hypothesized that if segments of the colon were resected, then production and...

2011
Farrell Cahill Jennifer L Shea Edward Randell Sudesh Vasdev Guang Sun

Background: Peptide YY (PYY), a gut hormone that inhibits appetite, has been linked to the development of obesity. Objective: This study investigated the nutritional regulation of PYY after 7 d of overfeeding (70% above normal energy requirements) in normal-weight, overweight, and obese men. Design: Sixty-nine men (aged 19–29 y) participated in the study. We analyzed the relation between fastin...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2006
Linda K Curtiss

Macrophages have the right tools to synthesize all the free cholesterol they need. If macrophages also could degrade cholesterol when they have too much, the concept of in vivo reverse cholesterol transport (RCT) would be irrelevant. Fortunately for those of us who do research in this area, the ability of macrophages to closely regulate their cellular cholesterol levels is accomplished not by c...

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