In the 18th century, doctrine of mercantilism-cameralism penetrated Russia and became basis for concept state accounting, which was implemented in Admiralty Regulation (1722), first Russian accounting law. The is a unique testimony to earliest experience adoption economic ideology Western style Russia. It brought an understanding importance procedures, budgeting control. aim this study show how...

In the clinic, immune checkpoint immunotherapy (ICI) is used to re-activate reactions against tumor neoantigens, leading striking remission in cancer patients’ tumors. However, complete or durable responses ICI treatment only occur a minority of patients. While level mutational burden (TMB) can be as predictive marker for responsiveness, we questioned whether subcellular localization neoantigen...