Klaudy Kingának, az ELTE Fordítástudományi Doktori Iskola vezetőjének és oktatójának a szakmai élete tevékenysége kezdetektől összefonódik magyarországi fordítástudomány önálló tudományágként való megszilárdításával.

01W AND GRONWALL (1) [N 1952 first applied the histochemical method of Hotchkiss for staining carbohydrates. In principle the polysaccharides are oxidized by periodic acid to give polyaldehydes, which yield violet-red compounds with Schiff ‘s reagent, fuchsin sulfite. K#{246}iw’s procedure, although giving excellent results when the glycoprotein was separated electrophoretically on filter paper...

TP53 is the most frequently mutated gene in cancer. The p53 protein activates transcription of genes that promote cell cycle arrest or apoptosis, or regulate cell metabolism, and other processes. Missense mutations in TP53 abolish specific DNA binding of p53 and allow evasion of apoptosis and accelerated tumor progression. Mutant p53 often accumulates at high levels in tumor cells. Pharmacologi...

The evidence that proteasomes are involved in the processing of cross-presented proteins is indirect and based on the in vitro use of proteasome inhibitors. It remains, therefore, unclear whether cross-presentation of MHC class I peptide epitopes can occur entirely within phagolysosomes or whether it requires proteasome degradation. To address this question, we studied in vivo cross-presentatio...

Electrophoretic and fingerprinting studies in a patient with congenital hemolytic anemia revealed the presence of the unstable hemoglobin K#{246}ln(f398 vat-suet). Examination of parents and siblings gave normal results. Extensive blood group and isozyme studies were consistent with the thesis that Hb K#{246}lndisease in the propositus was the result of a fresh mutation in one of his parent’s g...

Neural precursor cell expressed, developmentally down-regulated protein 4-2 (Nedd4-2) mediates the internalisation / degradation of epithelial Na(+) channel subunits (α-, β- and γ-ENaC). Serum / glucocorticoid inducible kinase 1 (SGK1) and protein kinase A (PKA) both appear to inhibit this process by phosphorylating Nedd4-2-Ser(221), -Ser(327) and -Thr(246). This Nedd4-2 inactivation process is...

UNLABELLED The International Diabetes Federation reported that 246 million adults worldwide had diabetes mellitus and the prevalence of this syndrome was expected to increase continuously. AIM To design new compound with potential antidiabetic and antioxidant activity. MATERIAL AND METHODS New benzylidene-thiazolidine derivatives (BT2a-2e) were obtained by condensation of xanthine-thiazolid...

Sulphosalts in the system CuSbSrCuBiS2 (chalcostibite-emplectite) form a complete solid solution series. Seven compositions with the general formula Cu(SbxBi1_x)S2 have been synthesized using dry methods at 310°C. All members of the series are orthorhombic (space group Pnma) and show smoothly increasing a and b cell parameters with substitution of Bi for Sb; the c cell parameter increases up to...