Neurotrophins are growth factors that are important in neuronal development and survival as well as synapse formation and plasticity. Many of the effects of neurotrophins are mediated by changes in protein expression as a result of altered transcription or translation. To determine whether neurotrophins regulate the production of microRNAs (miRNAs), small RNA species that modulate protein trans...

TNF-related apoptosis-inducing ligand (TRAIL) is a promising antitumor agent for its remarkable ability to selectively induce apoptosis in cancer cells, without affecting the viability of healthy bystander cells. The TRAIL tumor suppressor pathway is deregulated in many human malignancies including lung cancer. In human non-small cell lung cancer (NSCLC) cells, sensitization to TRAIL therapy ca...

We present a model of agents facing the uncertainty of two future forms of government who are able to insure against this uncertainty by hiding funds from taxation. In order to choose whether or not to hide funds from taxation, agents need to know policy choices that each government would make should it come to power. But each government, before it could make its decision, would need to know th...

heterocycles. Substitution reactions of 1(2H)-isoquinolone derivatives have been reported, however, little attention has been focused on addition reactions. Dyke et al. reported a Diels–Alder (DA) reaction of 2-methyl-1(2H)-isoquinolone derivatives as the diene. To the best of our knowledge, however, there have been no reports of a DA reaction of 1(2H)isoquinolones acting as dienophiles. DA rea...

HH 212 is a nearby (460 pc) protostellar jet discovered in H2 powered by a Class 0 source, IRAS 05413-0104, in the L1630 cloud of Orion. It is highly collimated and symmetric with matched pairs of bow shocks on either side of the source. We have mapped it in 850 μm continuum, SiO (J = 8− 7), CO (J = 3−2), SO (NJ = 89−78), HCO + (J = 4−3), and HCO (J = 4−3) emission simultaneously at ∼ 1 resolut...

The Fabry–Perot scanning interferometer mounted on the 6-m telescope of the Special Astrophysical Observatory of the Russian Academy of Sciences is used to study the distribution and kinematics of ionized gas in the peculiar galaxy Arp 212 (NGC7625, III Zw102). Two kinematically distinct subsystems—the inner disk and outer emission filaments—are found within the optical radius of the galaxy. Th...

Background and aims: Retractions are published in journals in order to correct, ensure the accuracy and integrity of literature and avoid of misconducts. Hence, retraction is an important mechanism in scientific accreditation especially in health subject. In the recent years, the numbers of retracted scientific articles have been increased but compared with the growth of total publications, it ...

The prognostic value of the carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) in melanoma was demonstrated more than a decade ago as superior to Breslow score. We have previously shown that intercellular homophilic CEACAM1 interactions protect melanoma cells from lymphocyte-mediated elimination. Here, we study the direct effects of CEACAM1 on melanoma cell biology. By employing tissue...

MicroRNAs (miRNAs) that regulate mRNA stability have been linked to amyloid production, tau phosphorylation, and inflammation in Alzheimer's disease (AD). However, whether cerebral miRNA networks are dysregulated during the earliest stages of AD remains underexplored. We performed miRNA expression analysis using frontal cortex tissue harvested from subjects who died with a clinical diagnosis of...

Today, reusable components are available in several repositorys. These are certainly conceived for re-use. However, this re-use is not immediate, it requires, in effect, to pass by some essential conceptual operations, among which in particular, research, integration, adaptation, and composition. We are interested in the present work to the problem of semantic integration of heterogeneous Busin...