نتایج جستجو برای: 16a
تعداد نتایج: 367 فیلتر نتایج به سال:
Most organisms depend on iron as a co-factor for proteins catalyzing redox reactions. Iron is, however, a difficult element for cells to deal with, as it is insoluble in its ferric (Fe3+) form and potentially toxic in its ferrous (Fe2+) form. Thus, in vertebrates iron is transported through the circulation bound to transferrin (Tf) and delivered to cells through an endocytotic cycle involving t...
Meier-Gorlin syndrome (MGS) is a genetically heterogeneous primordial dwarfism syndrome known to be caused by biallelic loss-of-function mutations in one of five genes encoding pre-replication complex proteins: ORC1, ORC4, ORC6, CDT1, and CDC6. Mutations in these genes cause disruption of the origin of DNA replication initiation. To date, only an autosomal-recessive inheritance pattern has been...
A comprehensive study of the magnetic properties of Y3−2xCa2xFe5−xVxO12 (0 ≤ x ≤ 1) has been performed. The garnet ferrites samples were prepared by the ceramic technique, and X-ray diffraction analysis indicates the formation of single cubic phase. Vibrating sample magnetometry (VSM) and a superconducting quantum-interference device (SQUID) were used to measure the magnetic properties, especia...
Multiple myeloma (MM) remains incurable, and MM-initiating cells or MM progenitors are considered to contribute to disease relapse through their drug-resistant nature. In order to improve the therapeutic efficacy for MM, we recently developed novel superparamagnetic nanoparticles which selectively accumulate in MM tumors and extirpate them by heat generated with magnetic resonance. We here aime...
Although 17β-estradiol (E2) deficiency has been linked to the development of osteoarthritis (OA) in middle-aged women, there are few studies relating other estrogens and estrogen metabolites (EMs) to this condition. We developed a high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (HPLC-ESI-MS/MS) method to measure the levels of six EMs (i.e., estrone, E2, e...
Improve the performance of remotely situated device control and data monitoring, acquisition with parameter such as temperature, pressure, vibration, humidity on real time basis give the data modularity as well as low data processing time. The infrastructure of the existing RF network is used, which is based on supervisory control, monitoring and data acquisition demands constant development an...
Wnts are small secreted glycoproteins that are highly conserved among species. To date, 19 Wnts have been described, which initiate a signal transduction cascade that is either β-catenin dependent or independent, culminating in the regulation of hundreds of target genes. Extracellular release of Wnts is dependent on lipidation of Wnts by porcupine, a membrane-bound-O-acyltransferase protein in ...
A series of 1-(N-substituted-1H-indol-3-yl)-3-arylprop-2-ene-1-ones (2a, b-4a, b) were prepared and allowed to react with urea, thiourea or guanidine to give pyrimidine derivatives 5a, b-13a, b. Reaction of 2a, b-4a, b with ethyl acetoacetate in the presence of a base gave cyclohexanone derivatives 14a, b-16a, b. Reaction of the latter compounds with hydrazine hydrate afforded indazole derivati...
A dual-rate 4.7/6.5 kbits/s algebraic code excited linear predictive (ACELP) codec is proposed for adapt ive speech communicators, which can d r o p their source ra te a n d speech quali ty under network control i n order t o invoke a more e r ro r resilient modem amongst less favourable channel conditions. Sourcematched Bose-Chaudhuri-Hocquenghem (BCH) codecs combined with un-equal ,protection...
We observed a 17×17 region of the ρ Oph molecular cloud, using the ACIS-I array onboard the Chandra X-ray Observatory (CXO). A 100-ks exposure observation revealed ∼ hundred X-ray sources above the detection limit of ∼ 10 ergs s. About 2/3 of the X-ray sources are identified to an optical and/or infrared counterpart, including significant numbers of class I, II and III sources and a few brown d...
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