Phototherapy was developed in the late 1950s and is today considered the mainstay of managing neonatal jaundice. Yet prominent academic leaders continued to promote the older approach of exchange transfusion well into the 1970s, despite the considerable risks involved. This article explores why phototherapy took so long to be embraced, and how pediatric residents were caught in the middle of th...

Background: Infant jaundice is one the most common causes of hospitalization in infant in the first month of birth, which is defined an abnormal increase in blood bilirubin levels. Exchange transfusion is the recommended treatment for neonatal jaundice who do not respond to phototherapy and experience dangerous complication of jaundice and signs of kernicterus. However, this treatment may lead ...

Automated method for exchange transfusion Sir, Philpott and Banerjee (Archives, 1972) are to be congratulated on their method of exchange transfusion using a two-channel Holter pump. Many have been interested in this technical problem, and the Holter pump provides an acceptable solution. The pumping rate of the machine is accurate to ±3%. More importantly, the discrepancy between the flow rates...

I N PREVIOUS papers,1 ’ a method of treating erythroblastotic infants by cxchange transfusion was describcd. In the cases reported, the disease had been produced by sensitization to the Rh factor. Despite the publication of several well documented reports,6 it is still not universally appreciated that typical erythroblastosis can also, though rarely, result from sensitization to the A and B fac...

where v is the total exchanged volume, V is the patient's blood volume and e is the transcendental number, base of the natural logarithm. However, he later stated that his formula was not correct because it did not take into consideration the difference between the patient's haematocrit and that of the transfused blood. Moreover, according to others, even when the two haematocrits happen to be ...

Wood, Ben, Comley, Ann, and Sherwell,Janet (1970). Archives of Disease in Childhood, 45, 59. Effect of additional albumin administration during exchange transfusion on plasma albumin and reserve albumin-binding capacity. A total of 33 infants undergoing exchange transfusion for hyperbilirubinaemia was divided into two albumin-treated groups and a control group. Both albumin-treated groups showe...

A young man presented with abdominal pain and vomiting after eating Naphthalene Mothball. He had dyspnea, central cyanosis (SaO2 on air was 67% air), marked pallor, deep jaundice dehydration. His urine color black; and, his plasma in clotted blood sample brownish. treated as methemoglobinemia due to suicidal Mothball poisoning fluid electrolyte replacement, ascorbic acid, N-acetylcystine exchan...

Tan et al are to be congratulated for achieving the difficult task of synthesizing the many disparate pieces of data on the subject of exchange transfusion (ET) [1]. However, we believe their conclusion that “adjunct ET cannot be recommended” should have been qualified with an acknowledgment that they have shown a “lack of evidence for benefit” rather than “evidence for lack of benefit.” The re...