It was 7:15 on a Tuesday evening in early September, and Irving Weissman, MD, needed a birthday cake, stat. His daughter, Rachel, was turning 22 the next day. Fresh from fishing the Bitterroot River, clad in khakis and a long-sleeved beige shirt and in stocking feet, he picked up the phone to begin cajoling a local bakery to rustle up a cake big enough to serve several dozen people. “You’d thin...

ALICEROBBIN ABSTRACT THISARTICLE EXAMINES SELECTED ECONOMIC and social indicators of our multiracial and multiethnic society at the end of the twentieth century to provide an information base for wise decisions about effective library services. The statistical profile describes the demography, economic well-being , and educational attainment of the principal racial and Hispanic origin groups. T...

According to the increased fungi contaminations and related damages, microbiologist's incentive in considering the fungal contaminations in human habitats had increased. Some of fungi cause disease through production of toxins in animals as well as humans. Since these toxins are not easily distinguishable, then it is crucial to study their characteristics. Aspergillus are among the most importa...

Deoxynivalenol (DON) is a protein synthesis inhibitor produced by the Fusarium species, which frequently contaminates grains used for human or animal consumption. We treated a wheat suspension culture with DON or one of its acetylated derivatives, 3-acetyl-DON (3-ADON), 15-acetyl-DON (15-ADON) and 3,15-diacetyl-DON (3,15-diADON), and monitored the metabolization over a course of 96 h. Supernata...

BACKGROUND Clinical significance of delayed-onset neutropenia (DON) after autologous hematopoietic stem-cell transplantation (ASCT) has not been well described. We conducted a retrospective cohort study to examine risk factors and clinical impact of DON. DESIGN AND METHODS Subjects were consecutive 108 patients with B-cell lymphoma receiving ASCT. We defined DON as absolute neutrophil counts ...

The Fusarium mycotoxin deoxynivalenol (DON) can cause cell death in wheat (Triticum aestivum), but can also reduce the level of cell death caused by heat shock in Arabidopsis (Arabidopsis thaliana) cell cultures. We show that 10 μg mL(-1) DON does not cause cell death in Arabidopsis cell cultures, and its ability to retard heat-induced cell death is light dependent. Under dark conditions, it ac...

The 21 Century Military is shifting its focus from traditional combat operations to stability, security, transition, and reconstruction (SSTR) operations (Department of Defense Directive, 2005). US policy on SSTR operations requires full interoperability among representatives across US Departments and Agencies, foreign governments and security forces, international organizations, US and foreign...

Based on prior observations that deoxynivalenol (DON) toxicity is sex-dependent, we compared metabolism and clearance of this toxin in male and female mice. Following intraperitoneal challenge with 1 mg/kg bw DON, the dose used in the aforementioned toxicity study, ELISA and LC-MS/MS analyses revealed that by 24 h, most DON and DON metabolites were excreted via urine (49-86%) as compared to fec...

An experiment was carried out to examine the effects of feeding Fusarium toxin-contaminated wheat (8.21 mg deoxynivalenol (DON) and 0.09 mg zearalenone (ZON) per kg dry matter) at different feed intake levels on the biotransformation and carry-over of DON in dairy cows. For this purpose, 14 ruminal and duodenal fistulated dairy cows were fed a diet containing 60% concentrate with a wheat portio...