INTRODUCTION The use of vasoconstrictors combined with local anaesthetics (LAs) in dentistry for patients with cardiovascular disease (CVD) is still controversial in the scientific literature. It raises concerns regarding the possibility of transient episodes, triggering negative cardiovascular outcomes. METHOD/DESIGN Trials eligible for our systematic review will enrol patients with CVD who ...

Increased vascular sensitivity to vasoconstrictors, such as angiotensin II and epinephrine, is observed in preeclampsia (PE). Recently, it was suggested that abnormal endothelial function might contribute to the pathophysiologic changes in PE. We investigated vasoconstrictor (angiotensin II and epinephrine)-induced endothelin-1 (ET-1) release from human umbilical vein endothelial cells incubate...

Pulmonary arterial hypertension (PAH) is a devastating disease mediated by vasoconstriction and vascular remodeling of the pulmonary vasculature. Current therapies target imbalance vasoconstrictors vasorelaxants in 3 pathways: nitric oxide, prostacyclin, endothelin. While these have extended lifespans for PAH patients, significant morbidity mortality remains. Notably, progress therapy over deca...

Hypertension is a disease of relatively normal blood flow and increased vascular resistance. The search for neural and humoral vasoconstrictors to explain this pattern has not produced convincing evidence in most cases. Autoregulatory vasoconstriction is an alternative explanation supported by Borst, Ledingbam and others; the validity of this idea is strengthened by frequent observations of rel...

In order to obtain an adequate impression of demarcation line area of a prepared tooth located in or below the gingival edge it is necessary to perform the dilatation and drying of the gingival sulcus using retraction cord impregnated with adequate retraction agents. The aim of the study was to carry out comparative analysis of advantages and disadvantages of commercially available gingival ret...