نتایج جستجو برای: vardenafil

تعداد نتایج: 378  

Journal: :Endocrinology 2012
Christoph Zenzmaier Johann Kern Natalie Sampson Martin Heitz Eugen Plas Gerold Untergasser Peter Berger

Phosphodiesterase type 5 (PDE5) inhibitors have been demonstrated to improve lower urinary tract symptoms secondary to benign prostatic hyperplasia (BPH). Because BPH is primarily driven by fibroblast-to-myofibroblast trans-differentiation, this study aimed to evaluate the potential of the PDE5 inhibitor vardenafil to inhibit and reverse trans-differentiation of primary human prostatic stromal ...

2014
Mehmet Aziret Oktay Irkorucu Enver Reyhan Hasan Erdem Koray Das Selvinaz Ozkara Ali Surmelioglu Selim Sozen Ilhan Bali Sulleyman Cetinkunar Kamuran Cumhur Deger

OBJECTIVES Vardenafil enhances dilatation of vascular smooth muscle and inhibits platelet aggregation. The purpose of this study was to evaluate the clinical effects of vardenafil and pentoxifylline administration in an experimental model of ischemic colitis. METHODS Forty female Wistar albino rats weighing 250-300 g were randomized into five experimental groups (each with n = 8) as follows:1...

Journal: :pharma-kritik 2004

2003
Craig I Coleman

Erectile dysfunction (ED) is defined as the inability to attain and/or maintain penile erection sufficient for satisfactory sexual performance.1 The Massachusetts Male Aging Study, a cross-sectional, community-based, random-sample survey, suggests that 10 million to 30 million men in the United States suffer from ED, with more than 900,000 estimated new cases annually.2 A higher prevalence of E...

2012
Tae Hee Lee Joon Seong Lee Su Jin Hong Seong Ran Jeon Wan Jung Kim Hyun Gun Kim Joo Young Cho Jin-Oh Kim

BACKGROUND/AIMS To evaluate the effects of the phosphodiesterase type 5 (PDE5) inhibitor vardenafil on esophageal function, including bolus transit, using multichannel intraluminal impedance and esophageal manometry (MII-EM). METHODS Sixteen healthy volunteers (15 men) underwent an MII-EM study including 10 liquid swallows and 10 viscous swallows in a seated position after fasting. Then, each...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2010
Makoto Sahara Masataka Sata Toshihiro Morita Toshiaki Nakajima Yasunobu Hirata Ryozo Nagai

OBJECTIVE We examined whether phosphodiesterase-5 (PDE5) inhibition can promote ischemia-induced angiogenesis. METHODS AND RESULTS Unilateral hindlimb ischemia was generated by resecting right femoral artery in wild-type C3H/He mice, treated with either vehicle or a PDE5 inhibitor vardenafil (10 mg/kg per day). Four weeks after surgery, vardenafil significantly enhanced blood flow recovery an...

Journal: :The Journal of pharmacology and experimental therapeutics 2006
Cleber E Teixeira Fernanda B M Priviero R Clinton Webb

Presumably, the vasorelaxant properties of phosphodiesterase type 5 (PDE5) inhibitors are similar in isolated blood vessels. We aimed to explore the mechanisms underlying the vasorelaxation induced by the selective PDE5 inhibitors sildenafil, vardenafil, and tadalafil in the rat aorta. Aortic rings were mounted in 5-ml organ baths, and concentration-response curves for PDE5 inhibitors (0.0001-1...

2009
Antonio Martín Morales Vincenzo Mirone John Dean Pierre Costa

Many men with erectile dysfunction (ED) also have associated underlying cardiovascular and metabolic conditions, for which they are likely to be taking medication. Therefore, cardiovascular safety and potential drug interactions are two of the major concerns when using PDE-5 inhibitors in these patients. The PDE-5 inhibitor, vardenafil, is characterized by a rapid onset of action, increased dur...

Journal: :The American journal of psychiatry 2006
Raymond Rosen Ridwan Shabsigh Mark Berber Pierre Assalian Mathew Menza Luis Rodriguez-Vela Robert Porto Keith Bangerter Monica Seger Francesco Montorsi

OBJECTIVE Erectile dysfunction and depression are highly associated. Previous studies have shown benefits of phosphodiesterase-5 inhibitor treatment for erectile dysfunction associated with antidepressant therapy or subsyndromal depression. The present study assessed the safety and efficacy of vardenafil in men with erectile dysfunction and untreated mild depression. METHOD In this 12-week, m...

Journal: :Profiles of drug substances, excipients, and related methodology 2011
Alaa A-M Abdel-Aziz Yousif A Asiri Adel S El-Azab Mohamed A Al-Omar Takehisa Kunieda

Tadalafil is PDE5 inhibitor that has recently been approved for the treatment of ED. The mechanism of action of tadalafil is similar to sildenafil and vardenafil through the inhibition of PDE. In both chemical structure and PDE subtype selectivity profile, tadalafil differs markedly from sildenafil and vardenafil. Compared with sildenafil and vardenafil, tadalafil exhibits a prolonged plasma re...

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