نتایج جستجو برای: vaca c

تعداد نتایج: 1057856  

Journal: :Journal of bacteriology 2001
M S McClain P Cao H Iwamoto A D Vinion-Dubiel G Szabo Z Shao T L Cover

Helicobacter pylori, a gram-negative bacterium associated with gastritis, peptic ulceration, and gastric adenocarcinoma in humans, secretes a protein toxin, VacA, that causes vacuolar degeneration of epithelial cells. Several different families of H. pylori vacA alleles can be distinguished based on sequence diversity in the "middle" region (i.e., m1 and m2) and in the 5' end of the gene (i.e.,...

Journal: :Infection and immunity 2007
Junzo Hisatsune Eiki Yamasaki Masaaki Nakayama Daisuke Shirasaka Hisao Kurazono Yohtaro Katagata Hiroyasu Inoue Jiahuai Han Jan Sap Kinnosuke Yahiro Joel Moss Toshiya Hirayama

Treatment of AZ-521 cells with Helicobacter pylori VacA increased cyclooxygenase 2 (COX-2) mRNA in a time- and dose-dependent manner. A p38 mitogen-activated protein kinase (MAPK) inhibitor, SB203580, blocked elevation of COX-2 mRNA levels, whereas PD98059, which blocks the Erk1/2 cascade, partially suppressed the increase. Consistent with involvement of p38 MAPK, VacA-induced accumulation of C...

Journal: :Infection and immunity 1998
M de Bernard D Burroni E Papini R Rappuoli J Telford C Montecucco

Cells exposed to Helicobacter pylori toxin VacA develop large vacuoles which originate from massive swelling of membranous compartments at late stages of the endocytic pathway. When expressed in the cytosol, VacA induces vacuolization as it does when added from outside. This and other evidence indicate that VacA is a toxin capable of entering the cell cytosol, where it displays its activity. In...

Journal: :The Journal of biological chemistry 2003
Mark S McClain Hideki Iwamoto Ping Cao Arlene D Vinion-Dubiel Yi Li Gabor Szabo Zhifeng Shao Timothy L Cover

Helicobacter pylori secretes a toxin, VacA, that can form anion-selective membrane channels. Within a unique amino-terminal hydrophobic region of VacA, there are three tandem GXXXG motifs (defined by glycines at positions 14, 18, 22, and 26), which are characteristic of transmembrane dimerization sequences. The goals of the current study were to investigate whether these GXXXG motifs are requir...

Journal: :Molecular biology of the cell 2000
V Ricci A Galmiche A Doye V Necchi E Solcia P Boquet

Helicobacter pylori vacuolating toxin (VacA) causes vacuolation in a variety of cultured cell lines, sensitivity to VacA differing greatly, however, among the different cell types. We found that the high sensitivity of HEp-2 cells to VacA was impaired by treating the cells with phosphatidylinositol-specific phospholipase C (PI-PLC) which removes glycosylphosphatidylinositol (GPI)-anchored prote...

2014
Muhammad Junaid Sarbast Al-Gubare Muhammad Yousef Mathukorn Na Ubol Somphob Leetachewa Chatchai Muanprasat Chanan Angsuthanasombat Wanpen Chaicumpa Niaz Ali Gerd Katzenmeier

The vacuolating cytotoxin VacA produced by Helicobacter pylori induces the formation of large cytoplasmic vacuoles in host gastric epithelial cells as well as a release of cytochrome C from mitochondria resulting in cell apoptosis. Considerable sequence diversity in VacA relating to different degrees of disease severity is observed with clinical samples from a multitude of geographic places. In...

2014
Lucia Libanez Bessa Campelo Braga Maria Aparecida Alves de Oliveira Maria Helane Rocha Batista Gonçalves Fernando Kennedy Chaves Tiago Gomes da Silva Benigno Adriana Dias Gomes Cícero Igor Simões Moura Silva Charles Anacleto Sérgio de Assis Batista Dulciene Maria Magalhães Queiroz

Helicobacter pylori infection is one of the most common infections worldwide and is associated with gastric diseases. Virulence factors such as VacA and CagA have been shown to increase the risk of these diseases. Studies have suggested a causal role of CagA EPIYA-C in gastric carcinogenesis and this factor has been shown to be geographically diverse. We investigated the number of CagA EPIYA mo...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2004
Mark S Sundrud Victor J Torres Derya Unutmaz Timothy L Cover

Recent evidence indicates that the secreted Helicobacter pylori vacuolating toxin (VacA) inhibits the activation of T cells. VacA blocks IL-2 secretion in transformed T cell lines by suppressing the activation of nuclear factor of activated T cells (NFAT). In this study, we investigated the effects of VacA on primary human CD4(+) T cells. VacA inhibited the proliferation of primary human T cell...

2010
Dinorah N Martínez-Carrillo Elvira Garza-González Reyes Betancourt-Linares Trinidad Mónico-Manzano Cuauhtémoc Antúnez-Rivera Adolfo Román-Román Eugenia Flores-Alfaro Berenice Illades-Aguiar Gloria Fernández-Tilapa

BACKGROUND The association between proinflammatory cytokine gene polymorphisms and gastric diseases related to Helicobacter pylori varies by population and geographic area.Our objective was to determine if the IL-1B -511 T>C and -31 C>T polymorphisms and H. pylori vacA genotypes are associated with risk of chronic gastritis and gastric ulcer in a Mexican population. METHODS We conducted endos...

Forough Foroughi, Homayoon Zojaji Hossein Dabiri Leila Shokrzadeh Mahsa Molaei Mehrdad Hagh Azali Mohammad Reza Zali Reza Mashayekhi

  Background and Objective: Helicobacter pylori has several strains with different degrees of virulence. The aim of this study was to detect two major important virulence factors, cagA/vacA genotypes, and to determine correlations among different cagA/vacA genotypes and histological features of chronic gastritis in Iranian patients. Methods: In this cross- sectional study, Gastric bi...

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