BACKGROUND The Val34Leu mutation in the activation peptide of factor XIII (FXIIIA) correlates with a lower incidence of myocardial infarction and ischemic stroke but an increased risk for hemorrhagic stroke. We describe mass spectrometric detection of the activation peptide variants in human serum. METHODS We used differential peptide display (DPD) to compare comprehensive peptide maps from p...

Introduction: Recurrent pregnancy loss (RPL) is defined as two or more consecutive which occurs before the 20th weeks of pregnancies for last menstrual period. Hereditary cause thrombophilic gene mutations and polymorphism may play an essential role in RPLs. Material Method: 291 women with a history abortions study group 61 without miscarriages control were included study. In this we analysed e...

BACKGROUND: Monoterpenes and C13-norisoprenoids are key terpenoid compounds for wine aroma. The enzyme encoded by VviDXS1 participates in biosynthesis grapevine fruits gain-of-function mutations this gene lead to characteristic muscat OBJECTIVE: To assess contribution aroma variation Northwestern Iberian cultivars, we resequenced 111 cultivars compared grape juice terpenic composition 12 of the...

Background and objective: Thrombotic microangiopathic effects have been reported in Coronavirus Disease-2019 (COVID-19) patients. In the present study, we aimed to examine relationship between hereditary thrombophilia factors clinical picture severity of COVID-19 Methods: Ninety patients were included grouped according three groups: severe/critical (n=30), mild/moderate (n=30) asymptomatic (n=3...

Aim: To compare the D-Dimer levels in patients with mild COVID-19 disease and without hereditary thrombophilia.
 Material Method: Factor V Leiden (G1691A) mutation, methylene tetrahydrofolate gene mutation (C677T, A1298C), PAI-1 (4G-5G) FXIII (V34L) mutations were examined all included study for various reasons such as recurrent miscarriage venous embolism. Patients any thrombophilia group...