نتایج جستجو برای: tyrosinase inhibitor

تعداد نتایج: 214578  

Journal: :Zeitschrift fur Naturforschung. C, Journal of biosciences 2003
Isao Kubo Qing-Xi Chen Ken-Ichi Nihei José S Calderón Carlos L Céspedes

Anisic acid (p-methoxybenzoic acid) was characterized as a tyrosinase inhibitor from ani-seed, a common food spice. It inhibited the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) catalyzed by tyrosinase with an IC50 of 0.60 mM. The inhibition of tyrosinase by anisic acid is a reversible reaction with residual enzyme activity. This phenolic acid was found to be a classical noncompetitive in...

Journal: :The Journal of investigative dermatology 2009
Hideaki Fujita Tomonori Motokawa Takayuki Katagiri Sadaki Yokota Akitsugu Yamamoto Masaru Himeno Yoshitaka Tanaka

The melanosome is a highly specialized organelle where melanin is synthesized. Tyrosinase and tyrosinase-related protein-1 (Tyrp1) are major melanosomal membrane proteins and key enzymes for melanin synthesis in melanocytes. Inulavosin, a melanogenesis inhibitor isolated from Inula nervosa (Compositae), reduced the melanin content without affecting either the enzymatic activities or the transcr...

Journal: :Chemico-biological interactions 2011
Shashi K Kudugunti Helen Thorsheim Mohammad S Yousef Lan Guan Majid Y Moridani

Glutathione S-transferase (GST) and multidrug resistance-associated proteins (MRPs) play major roles in drug resistance in melanoma. In this study, we investigated caffeic acid phenethyl ester (CAPE) as a selective GST inhibitor in the presence of tyrosinase, which is abundant in melanoma cells. Tyrosinase bioactivates CAPE to an o-quinone, which reacts with glutathione to form CAPE-SG conjugat...

Journal: :Australian Journal of Biological Sciences 1951

2017
Bonggi Lee Kyoung Mi Moon Jong Seung Lim Yeojin Park Do Hyun Kim Sujin Son Hyoung Oh Jeong Dae Hyun Kim Eun Kyeong Lee Ki Wung Chung Hye Jin An Pusoon Chun Arnold Y. Seo Ju-Hye Yang Bong-Seon Lee Jin Yeul Ma Won-Kyung Cho Hyung Ryong Moon Hae Young Chung

Tyrosinase is a key player in ultraviolet-induced melanogenesis. Because excessive melanin accumulation in the skin can induce hyperpigmentation, the development of tyrosinase inhibitors has attracted attention in cosmetic-related fields. However, side effects including toxicity and low selectivity have limited the use of many tyrosinase inhibitors in cosmetics. We synthesized 12 novel 2-(subst...

2015
Francesca Pintus Delia Spanò Angela Corona Rosaria Medda Vijai Kumar Gupta

Tyrosinase is a well-known key enzyme in melanin biosynthesis and its inhibitors have become increasingly important because of their potential use as hypopigmenting agents. In the present study, the anti-melanogenic effect of aqueous and ethanolic extracts from Euphorbia characias leaves, stems, and flowers in cell-free and cellular systems was examined. All the extracts showed inhibitory effec...

Journal: :Biochemical and Biophysical Research Communications 2021

Excessive melanin formation has been linked to various skin disorders such as hyperpigmentation and cancer. Tyrosinase is the most prominent target for inhibitors of production. In this study, we investigated whether arbutin its prodrug, undecylenic acid ester, might inhibit phenoloxidase (PO), a tyrosinase-like enzyme. Molecular docking simulation results suggested that ester can bind substrat...

Introduction: Saffron has some applications such as anti-spasmodic and analgesic effects in traditional medicine. The aim of this study was to evaluate the anti melanogenesis and antioxidant properties of crocin (one of the saffron active components) on B16F10 mouse melanoma cell line. Methods: In this experimental study, B16F10 cells were prepared from Pasteur Institute (NCBI) and were grow...

Journal: :Molecules 2017
Eliza Chaita George Lambrinidis Christina Cheimonidi Adamantia Agalou Dimitris Beis Ioannis Trougakos Emmanuel Mikros Alexios-Leandros Skaltsounis Nektarios Aligiannis

In therapeutic interventions associated with melanin hyperpigmentation, tyrosinase is regarded as a target enzyme as it catalyzes the rate-limiting steps in mammalian melanogenesis. Since many known agents have been proven to be toxic, there has been increasing impetus to identify alternative tyrosinase inhibitors, especially from natural sources. In this study, we investigated 900 extracts fro...

2016
Batel Deri Margarita Kanteev Mor Goldfeder Daniel Lecina Victor Guallar Noam Adir Ayelet Fishman

Tyrosinases are responsible for melanin formation in all life domains. Tyrosinase inhibitors are used for the prevention of severe skin diseases, in skin-whitening creams and to avoid fruit browning, however continued use of many such inhibitors is considered unsafe. In this study we provide conclusive evidence of the inhibition mechanism of two well studied tyrosinase inhibitors, KA (kojic aci...

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