objective(s): p-glycoprotein (p-gp) is an efflux protein, the overexpression of which has been associated with multidrug resistance in various cancers. although sirna delivery to reverse p-gp expression may be promising for sensitizing of tumor cells to cytotoxic drugs, the therapeutic use of sirna requires effective carriers that can deliver sirna intracellularly with minimal toxicity on targe...

Objective(s): Low penetration depth of light is the main defect of photodynamic therapy (PDT), which could be improved by sonodynamic therapy (SDT). In this study, a combination of PDT and SDT known as sonophotodynamic therapy (SPDT) was investigated using two reverse arrangements in CT26 tumor model. Materials and Methods: The liposomal zinc phthalocyanine was synthesized and characterized. It...

Introduction: Glioma is the most common type of primary brain tumor that originates from glial tissues. These types of tumors have a high degree of malignancy and poor prognosis and low survival rates. The evaluation response to treatment is essential to decide whether present treatment is adequate or need for alternative therapy. The aim of this study was to evaluate the resp...

introduction: acoustic transient cavitation is the primary mechanism of sonochemical reaction and has potential use for tumor treatment. in this study, the in vivo anti-tumor effect of simultaneous dual-frequency ultrasound at low-level intensity (isata < 6 w/cm2) was investigated in a spontaneous murine model of breast adenocarcinoma in balb/c mice. materials and methods: forty tumor bearing m...

Background: Image-guided radiotherapy used multiple imaging during the radiation therapy course to improve the precision and accuracy of health care provider&#39;s treatment. Objectives: This study aims to assess the safety, effectiveness and economic aspects of image-guided radiation therapy for decision-making about this technology in Iran. Methods: In this study, the most important med...

Introduction: The proton beam produced in particle accelerators has an appropriate therapeutic potential. In this research, proton therapy of breast cancer is simulated using the MCNPX code in a MIRD phantom, also the contribution of scattered neutron dose during the proton therapy were calculated for the Heart, Lung and Liver.   Materials and Methods: For si...

Tumor vaccines, focusing on tailoring individual tumor antigens, have gained much attention in personalized therapy.

Introduction: Photothermal therapy using gold nanoshells is one of cancer therapy methods. Gold nanoshells generally consist of a silica core and a thin gold shell. Fe3O4@Au core-shell can be used for magnetic targeted therapy. The objective of this study was investigation of the photothermal effects of magnetically targeted Fe3O4@Au NPs and NIR laser irradiation on model of me...

background: image-guided radiotherapy used multiple imaging during the radiation therapy course to improve the precision and accuracy of health care provider's treatment. objectives: this study aims to assess the safety, effectiveness and economic aspects of image-guided radiation therapy for decision-making about this technology in iran. methods: in this study, the most important medical datab...