The inhibition of triosephosphate isomerase (TPI) in glycolysis by the pyruvate kinase (PK) substrate phosphoenolpyruvate (PEP) results in a newly discovered feedback loop that counters oxidative stress in cancer and actively respiring cells. The mechanism underlying this inhibition is illuminated by the co-crystal structure of TPI with bound PEP at 1.6 Å resolution, and by mutational studies g...

The complete gene encoding Schistosoma mansoni triosephosphate isomerase (TPI) was isolated from a lambda phage genomic library on 2 overlapping clones. These genomic clones have been characterized by restriction mapping and DNA sequencing of the 5' flanking region, the exons, the intron boundaries and the polyadenylation addition site. S. mansoni TPI is encoded by 6 exons spanning a region of ...

TPI deficiency glycolytic enzymopathy is a progressive neurodegenerative condition that remains poorly understood. The disease is caused exclusively by specific missense mutations affecting the triose phosphate isomerase protein (TPI) and clinically features hemolytic anemia, adult-onset neurological impairment, degeneration, and reduced longevity. TPI has a well-characterized role in glycolysi...

Triosephosphate isomerase (TPI) is highly expressed in many human cancers and is involved in migration and invasion of cancer cells. However, TPI clinicopathological significance and prognostic value in gastric cancer (GC) are not yet well defined. The aim of the present work was to evaluate TPI expression in GC tissue and its prognostic value in GC patients.TPI expression was analyzed in 92 pr...

We present a new algorithm (called TPI /BDD) for computing the theory prime implicates compilation of a knowledge base X. In contrast to many compilation algorithms, TPI /BDD does not require the prime implicates of Z to be generated. Since their number can easily be exponential in the size of X, TPI/BDD can save a lot of computing. Thanks to TPI/BDD, we can now conceive of compiling knowledge ...

The current work aims to study the role of Microbial TPI in regulating the Human Lung cancer. Studies showed that there was a relative increase in the activity of the TPI in the patients suffering with cancer. The protein showed an increased expression in colon and bladder carcinomas. The study was undertaken to un reveal the molecular basis of this relation and also to prove the same. The arti...

Triose phosphate isomerase (TPI) deficiency glycolytic enzymopathy is a progressive neurodegenerative condition that remains poorly understood. The disease is caused exclusively by specific missense mutations affecting the TPI protein and clinically features hemolytic anemia, adult-onset neurological impairment, degeneration, and reduced longevity. TPI has a well-characterized role in glycolysi...

OBJECTIVES To assess the practice of testicular prosthesis insertion (TPI) related to orchidectomy in one geographical region and to identify the difference in the rates of insertion among different age groups. PATIENTS AND METHODS Males who underwent orchidectomy between 1989 and 2009 were identified from data collected from Scottish Morbidity Records. Patients were classified into six age g...

TPI can be used to improve the pseudo-random testability of circuit. However, many TPI algorithms are based on COP, which can only cope with Boolean circuits, while in the industry also three-state circuits are found. In this paper the testability analysis method COP and the COP based HCRF TPI algorithm are extended with three-state capabilities, and the HCRF TPI algorithm is adjusted in such a...

Efficient production testing is frequently hampered because current digital circuits require test sets which are too large. These test sets can be reduced significantly by means of Test Point Insertion (TPI). The state-of-the-art TPI methods only focus on solving one or two possible testability problems, and sometimes even fail to result in test set size reduction because they focus on the wron...